Comparative analysis of micro RNA expressions on between reactive lymphoid follicles and follicular lymphomas focusing to post-translational process.

反应性淋巴滤泡和滤泡性淋巴瘤之间微小RNA表达的比较分析，重点关注翻译后过程。

• 批准号: 20590366
• 负责人: KONDO Eisaku
• 金额: $ 3.08万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590366/
• 关键词: 分子病理; 濾胞性リンパ腫; microRNA; 胚中心; トランスジェニックマウス; B細胞性リンパ腫; リンパ腫; マイクロダイセクション

We planned the expression analysis of micro RNAs on between human follicular lymphomas (FLs) and their non-neoplastic counterpart, germinal centers (GCs) to elucidate the lymphomagenesis of FLs. From the results of miRNA profiling of human FLs in comparison with that of GCs, also of quantitative analysis by real-time PCR for sorted GC cells and FL cells, miR-146a and miR-193b revealed to be up-regulated in FLs than GCs, whereas miR-26a seemed to be down-regulated. Based on these results, we further generated transgenic mice overexpressing mouse miR-146a under regulation by immunoglobulin enhancer/promotor, and explore the phenotypic features of their B cells. Consequently, splenic GCs in miR-146a Tg mice seemed to be enlarged in response to stimulation by an exogenous antigen than those in wild type mice. The details are still under investigation now.

我们计划对人滤泡性淋巴瘤(FLS)和其非肿瘤性对应的生发中心(GCs)之间的microRNA进行表达分析，以阐明FLS的淋巴肿大机制。从人FLS与GCs的miRNA图谱比较，以及对分离的GC细胞和FL细胞的实时荧光定量分析结果显示，miR-146a和miR-193b在FLS中上调，而miR-26a似乎下调。基于这些结果，我们进一步获得了在免疫球蛋白增强子/启动子调控下高表达小鼠miR-146a的转基因小鼠，并探索了其B细胞的表型特征。因此，miR-146a转基因小鼠的脾GC在外源抗原刺激下似乎比野生型小鼠增大。目前细节仍在调查中。

项目成果

Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor, signaling

• DOI: 10.2353/ajpath.2008.070294
• 发表时间: 2008-01-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Akimzhanov, Askar;Krenacs, Laszlo;Serfling, Edgar
• 通讯作者: Serfling, Edgar

Bone Repair by Transplantation of hTERT-Immortalized Human Mesenchymal Stem Cells in Mice

• DOI: 10.1097/tp.0b013e3181ae5ba2
• 发表时间: 2009-08
• 期刊: Transplantation
• 影响因子: 6.2
• 作者: H. Nakahara;Haruo Misawa;Takahiro Hayashi;E. Kondo;Takeshi Yuasa;Yasuhiro Kubota;M. Seita;Hironobu Kawamoto;Wael Hassan;Reham A R A Hassan-Reham-A-R-A-Hassan-121641758;Shahid M Javed;Masato Tanaka;H. Endo;H. Noguchi;S. Matsumoto;K. Takata;Y. Tashiro;S. Nakaji;T. Ozaki;N. Kobayashi

Molecular targeting and imaging of gastric cancer metastasis

胃癌转移的分子靶向与成像

• 发表时间: 2011
• 作者: Aida J;Izumo T;Shimomura N;Nakamura K;Ishikawa N;Matsuura M;Poon SS;Fujiwara M;Sawabe M;Arai T;Takubo K;Hayao Nakanishi
• 通讯作者: Hayao Nakanishi

Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas

• DOI: 10.1136/jcp.2007.049825
• 发表时间: 2008-03-01
• 期刊: JOURNAL OF CLINICAL PATHOLOGY
• 影响因子: 3.4
• 作者: Sato, Y.;Ichimura, K.;Yoshino, T.
• 通讯作者: Yoshino, T.

Ocular adnexal IgG4-related disease has uniform clinicopathology

• DOI: 10.1111/j.1440-1827.2008.02257.x
• 发表时间: 2008-08-01
• 期刊: PATHOLOGY INTERNATIONAL
• 影响因子: 2.2
• 作者: Sato, Yasuharu;Ohshima, Koh-ichi;Yoshino, Tadashi
• 通讯作者: Yoshino, Tadashi