Physiological Function of Hormones Derived from Mesenchymal Cells and Its Failure

间充质细胞激素的生理功能及其失效

• 批准号: 21229013
• 负责人: NAKAO Kazuwa
• 金额: $ 135.62万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009-05-11 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21229013/
• 关键词: 内分泌学; 間葉系細胞由来ホルモン; ホルモン; 間葉系; 内分泌; レプチン; CNP; ナトリウム利尿ペプチド; レプシン; 軟骨; 脂肪組織; 脂肪委縮症; 間葉系細胞; 脂肪細胞; 心血管構成細胞; 肥満; 脂肪萎縮症; ANP; GC-B; レブチン

We demonstrated that the BP of CNP ecKO mice is significantly elevated. Their vascular relaxation reaction of mesenteric artery was diminished significantly. We showed that circulating CNP rescues chondrodysplastic CNP ko mice from impaired skeletal growth. We revealed that GC-A protects podocytes from aldosterone-induced glomerular injury.We demonstrated the insufficiency of postprandial suppression of food-related neural activity by fMRI and satiety feeling in lipodystrophic patients, which was restored by leptin, and that the beneficial effect of leptin /amylin coadministration on glucose and lipid metabolism in DIO mice. Owing to our investigator-initiated trial, marketing and manufacturing of recombinant human leptin for lipodystrophy were approved in 2013 in Japan. We demonstrated on adipogenic potential of human iPS/ES cells in vitro, and that these adipocytes can survive for at least 4 weeks after transplantation.

我们证明 CNP ecKO 小鼠的血压显着升高。其肠系膜动脉血管舒张反应明显减弱。我们发现循环 CNP 可挽救软骨发育不良 CNP ko 小鼠的骨骼生长受损。我们发现 GC-A 可以保护足细胞免受醛固酮诱导的肾小球损伤。我们通过 fMRI 和脂肪营养不良患者的饱腹感证明了餐后对食物相关神经活动的抑制不足，而瘦素可以恢复这种抑制，并且瘦素/胰岛淀粉样多肽联合给药对 DIO 小鼠的葡萄糖和脂质代谢具有有益作用。由于我们的研究者发起的试验，用于脂肪营养不良的重组人瘦素的营销和生产于 2013 年在日本获得批准。我们在体外证明了人类 iPS/ES 细胞的成脂潜力，并且这些脂肪细胞在移植后可以存活至少 4 周。

项目成果

Skeletal Analysis of the Long Bone Abnormality (lbab/lbab) Mouse, A Novel Chondrodysplastic C-Type Natriuretic Peptide Mutant

• DOI: 10.1007/s00223-011-9567-0
• 发表时间: 2012-04-01
• 期刊: CALCIFIED TISSUE INTERNATIONAL
• 影响因子: 4.2
• 作者: Kondo, Eri;Yasoda, Akihiro;Nakao, Kazuwa
• 通讯作者: Nakao, Kazuwa

Is pulse pressure a predictor of new-onset diabetes in high-risk hypertensive patients?: a subanalysis of the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial.

• DOI: 10.2337/dc09-1447
• 发表时间: 2010-05
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: Yasuno S;Ueshima K;Oba K;Fujimoto A;Hirata M;Ogihara T;Saruta T;Nakao K
• 通讯作者: Nakao K

Pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal fibrosis.

• DOI: 10.1038/ki.2011.305
• 发表时间: 2012-01
• 期刊: Kidney international
• 影响因子: 19.6
• 作者: H. Yokoi;M. Kasahara;K. Mori;Y. Ogawa;T. Kuwabara;Hirotaka Imamaki;T. Kawanishi;Kenichi Koga

Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias.

• DOI: 10.1507/endocrj.k10e-164
• 发表时间: 2010-08
• 期刊: Endocrine journal
• 影响因子: 2
• 作者: A. Yasoda;K. Nakao

Transcriptional Regulation of the Fetal Cardiac Gene Program

• DOI: 10.1254/jphs.12r04cp
• 发表时间: 2012-07-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Kuwahara, Koichiro;Nishikimi, Toshio;Nakao, Kazuwa
• 通讯作者: Nakao, Kazuwa