Physiological Function of Hormones Derived from Mesenchymal Cells and Its Failure

我们证明CNP ECKO小鼠的血压显著升高。肠系膜动脉的血管松弛反应明显减弱。我们发现，循环中的CNP可以拯救软骨发育不良的CNP Ko小鼠，使其免于骨骼生长受损。我们揭示了GC-A对醛固酮诱导的肾小球损伤的足细胞的保护作用。我们通过功能磁共振成像证实了脂肪营养不良患者餐后对食物相关神经活动的抑制不足，并通过瘦素恢复了患者的饱腹感，并证明了瘦素/胰淀素联合应用对DIO小鼠糖和脂代谢的有利作用。由于我们的研究人员发起的试验，用于治疗脂肪营养不良的重组人瘦素的营销和制造于2013年在日本获得批准。我们证实了体外培养的人iPS/ES细胞具有成脂潜能，移植后这些脂肪细胞可以存活至少4周。

We demonstrated that the BP of CNP ecKO mice is significantly elevated. Their vascular relaxation reaction of mesenteric artery was diminished significantly. We showed that circulating CNP rescues chondrodysplastic CNP ko mice from impaired skeletal growth. We revealed that GC-A protects podocytes from aldosterone-induced glomerular injury.We demonstrated the insufficiency of postprandial suppression of food-related neural activity by fMRI and satiety feeling in lipodystrophic patients, which was restored by leptin, and that the beneficial effect of leptin /amylin coadministration on glucose and lipid metabolism in DIO mice. Owing to our investigator-initiated trial, marketing and manufacturing of recombinant human leptin for lipodystrophy were approved in 2013 in Japan. We demonstrated on adipogenic potential of human iPS/ES cells in vitro, and that these adipocytes can survive for at least 4 weeks after transplantation.