Physiological Function of Hormones Derived from Mesenchymal Cells and Its Failure

我们证明了CNP ecKO小鼠的BP显著升高。肠系膜动脉血管舒张反应明显减弱。我们发现，循环CNP拯救软骨发育不良的CNP ko小鼠骨骼生长受损。我们揭示了GC-A保护足细胞免受醛固酮诱导的肾小球损伤，我们证明了脂肪营养不良患者通过fMRI和饱腹感对食物相关神经活动的餐后抑制不足，瘦素可以恢复这种抑制，并且瘦素/胰淀素联合给药对DIO小鼠的糖和脂质代谢具有有益作用。由于我们的制造商发起的试验，用于脂肪代谢障碍的重组人瘦素的上市和生产于2013年在日本获得批准。我们在体外证明了人iPS/ES细胞的成脂潜能，并且这些脂肪细胞在移植后可以存活至少4周。

We demonstrated that the BP of CNP ecKO mice is significantly elevated. Their vascular relaxation reaction of mesenteric artery was diminished significantly. We showed that circulating CNP rescues chondrodysplastic CNP ko mice from impaired skeletal growth. We revealed that GC-A protects podocytes from aldosterone-induced glomerular injury.We demonstrated the insufficiency of postprandial suppression of food-related neural activity by fMRI and satiety feeling in lipodystrophic patients, which was restored by leptin, and that the beneficial effect of leptin /amylin coadministration on glucose and lipid metabolism in DIO mice. Owing to our investigator-initiated trial, marketing and manufacturing of recombinant human leptin for lipodystrophy were approved in 2013 in Japan. We demonstrated on adipogenic potential of human iPS/ES cells in vitro, and that these adipocytes can survive for at least 4 weeks after transplantation.