课题基金 / 基金详情

Physiological Function of Hormones Derived from Mesenchymal Cells and Its Failure

Physiological Function of Hormones Derived from Mesenchymal Cells and Its Failure
间充质细胞激素的生理功能及其失效
批准号:
21229013
负责人:
NAKAO Kazuwa
金额:
$135.62万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009-05-11 至 2014-03-31

项目摘要

项目成果

NAKAO Kazuwa的其他基金

相关文献

中文摘要
翻译
我们证明CNP ECKO小鼠的血压显著升高。肠系膜动脉的血管松弛反应明显减弱。我们发现,循环中的CNP可以拯救软骨发育不良的CNP Ko小鼠,使其免于骨骼生长受损。我们揭示了GC-A对醛固酮诱导的肾小球损伤的足细胞的保护作用。我们通过功能磁共振成像证实了脂肪营养不良患者餐后对食物相关神经活动的抑制不足,并通过瘦素恢复了患者的饱腹感,并证明了瘦素/胰淀素联合应用对DIO小鼠糖和脂代谢的有利作用。由于我们的研究人员发起的试验,用于治疗脂肪营养不良的重组人瘦素的营销和制造于2013年在日本获得批准。我们证实了体外培养的人iPS/ES细胞具有成脂潜能,移植后这些脂肪细胞可以存活至少4周。
英文摘要
We demonstrated that the BP of CNP ecKO mice is significantly elevated. Their vascular relaxation reaction of mesenteric artery was diminished significantly. We showed that circulating CNP rescues chondrodysplastic CNP ko mice from impaired skeletal growth. We revealed that GC-A protects podocytes from aldosterone-induced glomerular injury.We demonstrated the insufficiency of postprandial suppression of food-related neural activity by fMRI and satiety feeling in lipodystrophic patients, which was restored by leptin, and that the beneficial effect of leptin /amylin coadministration on glucose and lipid metabolism in DIO mice. Owing to our investigator-initiated trial, marketing and manufacturing of recombinant human leptin for lipodystrophy were approved in 2013 in Japan. We demonstrated on adipogenic potential of human iPS/ES cells in vitro, and that these adipocytes can survive for at least 4 weeks after transplantation.
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DOI: 10.1007/s00223-011-9567-0
发表时间: 2012-04-01
期刊: CALCIFIED TISSUE INTERNATIONAL
影响因子: 4.2
作者: [Kondo, Eri, Yasoda, Akihiro, Nakao, Kazuwa]
通讯作者: Nakao, Kazuwa
DOI: 10.2337/dc09-1447
发表时间: 2010-05
期刊: Diabetes care
影响因子: 16.2
作者: [Yasuno S, Ueshima K, Oba K, Fujimoto A, Hirata M, Ogihara T, Saruta T, Nakao K]
通讯作者: Nakao K
DOI: 10.1038/ki.2011.305
发表时间: 2012-01
期刊: Kidney international
影响因子: 19.6
作者: [H. Yokoi;M. Kasahara;K. Mori;Y. Ogawa;T. Kuwabara;Hirotaka Imamaki;T. Kawanishi;Kenichi Koga;]
通讯作者: H. Yokoi;M. Kasahara;K. Mori;Y. Ogawa;T. Kuwabara;Hirotaka Imamaki;T. Kawanishi;Kenichi Koga;
DOI: 10.1507/endocrj.k10e-164
发表时间: 2010-08
期刊: Endocrine journal
影响因子: 2
作者: [A. Yasoda;K. Nakao]
通讯作者: A. Yasoda;K. Nakao
78
    Development and analysis of model rats for diseases of endocrinology and metabolism
    • 批准号:
      23659476
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2011
    • 负责人:
      NAKAO Kazuwa
    • 依托单位:
    Translational research and development of novel diagnostic/therapeutic modalities for metabolic syndrome based on adipocyte endocrinology and adiposcience
    • 批准号:
      16109007
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $73.22万
    • 财政年份:
      2004
    • 负责人:
      NAKAO Kazuwa
    • 依托单位:
    Molecular Basis of Centrally-controled Energy Homeostasis -Focusing on Leptin Resistance-
    • 批准号:
      13307033
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $35.36万
    • 财政年份:
      2001
    • 负责人:
      NAKAO Kazuwa
    • 依托单位:
    Clinical implication of cardiovascular hormones
    • 批准号:
      10307026
    • 项目类别:
      Grant-in-Aid for Scientific Research (A).
    • 资助金额:
      $24.83万
    • 财政年份:
      1998
    • 负责人:
      NAKAO Kazuwa
    • 依托单位: