Physiological Function of Hormones Derived from Mesenchymal Cells and Its Failure

我们证明了CNP ecKO小鼠的血压显著升高。肠系膜动脉血管舒张反应明显减弱。我们发现，循环CNP可使软骨发育不良的CNP小鼠免于骨骼生长受损。我们发现GC-A可以保护足细胞免受醛固酮引起的肾小球损伤。我们通过fMRI证明了脂肪营养不良患者餐后食物相关神经活动抑制不足，饱腹感通过瘦素恢复，瘦素/amylin共同给药对DIO小鼠葡萄糖和脂质代谢的有益作用。由于我们的研究者发起的试验，重组人瘦素治疗脂肪营养不良的销售和生产于2013年在日本获得批准。我们在体外证明了人类iPS/ES细胞的成脂潜力，并且这些脂肪细胞在移植后至少可以存活4周。

We demonstrated that the BP of CNP ecKO mice is significantly elevated. Their vascular relaxation reaction of mesenteric artery was diminished significantly. We showed that circulating CNP rescues chondrodysplastic CNP ko mice from impaired skeletal growth. We revealed that GC-A protects podocytes from aldosterone-induced glomerular injury.We demonstrated the insufficiency of postprandial suppression of food-related neural activity by fMRI and satiety feeling in lipodystrophic patients, which was restored by leptin, and that the beneficial effect of leptin /amylin coadministration on glucose and lipid metabolism in DIO mice. Owing to our investigator-initiated trial, marketing and manufacturing of recombinant human leptin for lipodystrophy were approved in 2013 in Japan. We demonstrated on adipogenic potential of human iPS/ES cells in vitro, and that these adipocytes can survive for at least 4 weeks after transplantation.