Molecular design of protein-based nanocapsulesfor multifunctional platforms

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The protein nanocapsules are self-organized complexes of protein oligomersand possess nanoscale inner cavities, and the three-dimensional architecture can be specified in complete detail. A variety of molecules including drugs and MRI contrast agents are encapsulated in the cavity. Such functionalized protein nanocapsules were applied to effective drug delivery, in vitro and in vivo bioimaging. The protein-based nanocapsules have the potential to offer special advantages in gaining new functions that show responsiveness to biochemical signals in many different cellular processes.