The development and clinical significance of laboratory examination on finger blood volume with light emitting diode during a non-invasive static pressurization

无创静态加压时发光二极管手指血容量实验室检查的进展及临床意义

• 批准号: 21300193
• 负责人: TANIGUCHI Nobuyuki
• 金额: $ 9.57万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300193/
• 关键词: 動脈硬化; 血管系検査; 検査診断学; 血管生物学; 糖尿病; 高血圧症; 脂質異常症; 生活習慣病; 血液流動性; 非侵襲的検査

It is important to understand the pathophysiology of micro-vessels in atherosclerotic diseases, but there have been no laboratory examinations for it. We have developed a novel method where the blood levels of finger capillary arteries, which were moved during a non-invasive static pressurization of the skin, were measured quantitatively based on the hemoglobin absorption by light emitting diode. The velocity pressure index(VPI) assessed by this method showed a clinically acceptable reproducibility and coefficient of variation. The diabetic patients exhibited a significantly lower VPI level than controls. The VPI level was significantly and positively correlated with several atherosclerotic risk factors such as obesity and serum lipids in these patients. The diabetic and hypertensive patients with longer sleep duration showed a significantly lower VPI level than those with adequate sleep duration. These data suggest that the present method we developed may be useful to observe the pathophysiology of capillary arteries in lifestyle-related diseases. Further studies are warranted to establish the utility of this examination in the clinical setting.

了解动脉粥样硬化性疾病中微血管的病理生理学很重要，但目前还没有对其进行实验室检查。我们开发了一种新的方法，根据发光二极管对血红蛋白的吸收来定量测量在皮肤非侵入性静压过程中移动的手指毛细血管的血液水平。用该方法计算的速度-压力指数(VPI)具有临床可接受的重复性和变异系数。糖尿病患者的VPI水平明显低于对照组。在这些患者中，VPI水平与肥胖、血脂等动脉粥样硬化危险因素呈显著正相关。睡眠时间较长的糖尿病和高血压患者的VPI水平明显低于睡眠时间充足的患者。这些数据表明，我们目前开发的方法可能有助于观察生活方式相关疾病的毛细血管的病理生理学。有必要进行进一步的研究，以确定该检查在临床环境中的实用性。