The development and clinical significance of laboratory examination on finger blood volume with light emitting diode during a non-invasive static pressurization

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It is important to understand the pathophysiology of micro-vessels in atherosclerotic diseases, but there have been no laboratory examinations for it. We have developed a novel method where the blood levels of finger capillary arteries, which were moved during a non-invasive static pressurization of the skin, were measured quantitatively based on the hemoglobin absorption by light emitting diode. The velocity pressure index(VPI) assessed by this method showed a clinically acceptable reproducibility and coefficient of variation. The diabetic patients exhibited a significantly lower VPI level than controls. The VPI level was significantly and positively correlated with several atherosclerotic risk factors such as obesity and serum lipids in these patients. The diabetic and hypertensive patients with longer sleep duration showed a significantly lower VPI level than those with adequate sleep duration. These data suggest that the present method we developed may be useful to observe the pathophysiology of capillary arteries in lifestyle-related diseases. Further studies are warranted to establish the utility of this examination in the clinical setting.