Spiral Formation of Exc itation Waves Based on Curvature Effect in Culture of Cardiomyocyt

基于曲率效应的心肌细胞培养中激励波的螺旋形成

• 批准号: 21340120
• 负责人: アグラゼ コンスタンチン
• 金额: $ 11.81万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21340120/
• 关键词: 非線形振動; 興奮性; 曲率効果; 心筋細胞; ラセン波; 反応拡散方程式; パターン形成; 光制御

Behaviors of traveling excitation waves around obstacle region in cultivated cardiomyocytes were investigated in experimentally and numerically. The instability of propagation waves were affected by excitability of the cells and shape of obstacle.Spontaneous formation of spiral wave at edge of sharp corner was also observed.Furthermore, new methods (1) to control activity of cardiomyocytes with the aid of photo-switching molecules, and (2) to construct aligned culture of cells along fabricated microfiber were established

通过实验和数值研究了培养的心肌细胞中障碍区域周围的行进激励波的行为。传播波的不稳定性受到细胞兴奋性和障碍物形状的影响。还观察到尖角边缘处自发形成螺旋波。此外，还建立了新方法（1）借助光开关分子控制心肌细胞的活性，以及​​（2）沿着制造的微纤维构建细胞对齐培养物

项目成果

Liberation of a pinned spiral wave by a single stimulus in excitable media

• DOI: 10.1103/physreve.79.026218
• 发表时间: 2009-02-01
• 期刊: PHYSICAL REVIEW E
• 影响因子: 2.4
• 作者: Horning, Marcel;Isomura, Akihiro;Yoshikawa, Kenichi
• 通讯作者: Yoshikawa, Kenichi

Digital photo-control of the network of live excitable cells

活体可兴奋细胞网络的数字光控制

• DOI: 10.1134/s0021364011180056
• 发表时间: 2011
• 期刊: J.Exp.Theor.Phys.Lett.
• 作者: I.S.Erofeev;N.Magome;K.Agladze
• 通讯作者: K.Agladze

Optical Control of Excitation Waves in Cardiomyocyte Culture

心肌细胞培养中激发波的光学控制

• 发表时间: 2010
• 作者: K. Kaneko;R. Settai;Y. Onuki;et al.;橋本武志・八神樹・寺田暁彦・江尻省・中村卓司・阿保真・吉川慎;M.Tateno;K. Hakuta;日高芳樹;N. Magome and K. Agladze
• 通讯作者: N. Magome and K. Agladze

Digital photo-control of cardiac tissue

心脏组织的数字光控制

• 发表时间: 2011
• 作者: 阪口隼也;摂待力生;大貫惇睦;他;Kaoru Ohno;アグラゼ コンスタンチン
• 通讯作者: アグラゼ コンスタンチン

Control of Structure and Excitability of Cardiomyocyte Culture

心肌细胞培养物结构和兴奋性的控制

• 发表时间: 2011
• 作者: N. Magome;Y. Orlova;L. Liu;Y. Chen;and K. Agladze
• 通讯作者: and K. Agladze