Synthetic Studies on Complex Terpenoids with Bioactivities as Lead Compounds of Agricultural Chemicals

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Potato cyst nematode is a troublesome parasite that live on, and destroy, important vegetable plants including potatoes. We have achieved the first total synthesis of solanoeclepin A, the key hatch-stimulating substance for potato cyst nematode, through 52-step transformations. The synthetic solanoeclepin A was shown to stimulate the hatching activity at high dilution in water, and the present synthesis has the potential to contribute to the critical food supply issue.