The development of self-assembly nano-devices based on electrostatic interaction and the application to selective drug delivery

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In this study, we developed the self-assembly nano-devices based on electrostatic interaction. We could prepare the stable nano-devices by changing the blend ratio of gene, cationic compounds and anionic compounds and the preparation procedures. The nano-devices containingγ-polyglutamic acid, N-lauroylsarcosine, or glycyrrhizin achieved high intracellular uptake without showing cytotoxicity and blood toxicity. After intravenous administration of these nano-devices in mice, selective high gene expression was observed in the spleen, lung, or liver by the difference of each component. Furthermore, we could mass-produce and freeze-dry nano-devices. In conclusion, we successfully developed the secure and effective nano-devices and revealed the preparation technic responding to therapeutic purpose.