Molecular mechanisms of the signal transductions by the factors functioning as a trigger for the adipocyte differentiation.

肥胖与2型糖尿病、高血压和高脂血症的发生有关。肥胖是由单个脂肪细胞的肥大和脂肪细胞的增生引起的。由于脂肪细胞增生是由前脂肪细胞形成成熟脂肪细胞，因此阐明脂肪细胞分化的分子机制具有重要意义。在这项研究中，包括新基因在内的许多基因被鉴定和表征。此外，两个新基因的敲除小鼠表明，这些基因在肺发育、骨形成和胚胎发育中起调节作用，表明这些关键基因在发育中具有多重功能。

Obesity is related to the development of type 2 diabetes mellitus, hypertension, and hyperlipidemia. Obesity results from hypertrophy of individual adipocytes and hyperplasia of adipocytes. Since hyperplasia of adipocytes is caused by the formation of mature adipocytes from preadipocytes, it is important to elucidate the molecular mechanism of adipocyte differentiation. In this study, many genes including novel genes were identified and characterized. Moreover, the knockout mice for two novel genes showed that these genes function as regulators for lung development, bone formation and embryonic development, indicating that these key genes have multiple functions in development.