Development of methodologies for catalytic decomposition of proteins

蛋白质功能的分析对于揭示细胞内未知现象和药物开发是必不可少的。我们在这项研究中的目的是发展催化分解蛋白质的方法，从而揭示蛋白质的功能。我们已经开发了各种各样的化学设计来阐明肽和蛋白质相关的事件，包括刺激响应氨基酸，肽模拟物和不可水解的磷酸氨基酸。在此基础上，我们发展了几种催化蛋白质分解的化学方法。

Analysis of protein functions has been indispensable for disclose of unknown cellar phenomena and drug development. Our purpose in this research is the development of methodologies for catalytic decomposition of proteins, which leads to the uncovering protein functions. We have developed a wide variety of chemical devise for elucidation of peptides-and proteins-associated events, including stimulus-responsive amino acids, peptide mimetics, and nonhydrolyzable phosphoamino acids. On the basis of these researches, we have developed several chemical means for the catalytic protein decomposition.