Role of stress response for differentiation and maturation of hematop oietic cells

应激反应对造血细胞分化和成熟的作用

• 批准号: 21390074
• 负责人: MOTOHASHI Hozumi
• 金额: $ 11.98万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390074/
• 关键词: 転写因子; 巨核球; 血小板; 細胞分化

This study aimed at clarifying how metabolic and oxidative stresses influence the proliferation and differentiation of hematopoietic cells from the viewpoint of CNC-Maf transcription factors. I found that NF-E2 p45 antagonize with Nrf2 and promotes the terminal differentiation of megakaryocytes resulting in the increase of intracellular reactive oxygen species. I also found that NF-E2 p45 directly activates the genes encoding the factors involved in the platelet function. In tumor-bearing mice, expression of NF-E2 p45 and its target genes was robustly increased

本研究旨在从CNC-Maf转录因子的角度阐明代谢和氧化应激如何影响造血细胞的增殖和分化。我发现NF-E2 p45拮抗Nrf 2，促进巨核细胞的终末分化，导致细胞内活性氧的增加。我还发现NF-E2 p45直接激活编码血小板功能相关因子的基因。在荷瘤小鼠中，NF-E2 p45及其靶基因的表达显著增加

项目成果

Stress response mechanisms by Keap1-Nrf2 regulatory system. Institut de Radiobiologie Cellulaire et Moleculaire

Keap1-Nrf2 调节系统的应激反应机制。

• 发表时间: 2010
• 作者: Ido A;Moriuchi A;Numata M;Murayama T;Teramukai S;Marusawa H;Yamaji N;Setoyama H;Kim ID;Chiba T;Higuchi S;Yokode M;Fukushima M;Shimizu A. and Tsubouchi H.;Hozumi Motohashi
• 通讯作者: Hozumi Motohashi

NF-E2 p45 N-terminal Region Is Essential for Transactivation Mediating Thrombogenesis

NF-E2 p45 N 末端区域对于反式激活介导血栓形成至关重要

• 发表时间: 2009
• 作者: Mariko Takayama;Rie Fujita;Hozumi Motohashi;Masayuki Yamamoto
• 通讯作者: Masayuki Yamamoto

血小板形成における転写因子NF-E2 p45 N末端領域の重要性

转录因子 NF-E2 p45 N 末端区域在血小板形成中的重要性

• 发表时间: 2009
• 作者: 高山昌理子;井上あい;藤田理恵;本橋ほづみ;山本雅之
• 通讯作者: 山本雅之

Survival Strategy and Disease Pathogenesis According to the Nrf2-Small Maf Heterodimer. Oxidative Stress in Vertebrates and Invertebrates. Wiley-Blackwell

根据 Nrf2-Small Maf 异二聚体的生存策略和疾病发病机制。

• 发表时间: 2011
• 作者: Sajdel-Sulkowska EM;Sulkowski ZL;Xu M;Koibuchi N;Morita M and Motohashi H.
• 通讯作者: Morita M and Motohashi H.

Molecular Determinants for Small Maf Protein Control of Platelet Production

• DOI: 10.1128/mcb.00798-10
• 发表时间: 2011-01-01
• 期刊: MOLECULAR AND CELLULAR BIOLOGY
• 影响因子: 5.3
• 作者: Motohashi, Hozumi;Fujita, Rie;Yamamoto, Masayuki
• 通讯作者: Yamamoto, Masayuki