Role of stress response for differentiation and maturation of hematop oietic cells

本研究旨在从CNC-Maf转录因子的角度阐明代谢和氧化应激如何影响造血细胞的增殖和分化。我发现NF-E2 p45拮抗Nrf 2，促进巨核细胞的终末分化，导致细胞内活性氧的增加。我还发现NF-E2 p45直接激活编码血小板功能相关因子的基因。在荷瘤小鼠中，NF-E2 p45及其靶基因的表达显著增加

This study aimed at clarifying how metabolic and oxidative stresses influence the proliferation and differentiation of hematopoietic cells from the viewpoint of CNC-Maf transcription factors. I found that NF-E2 p45 antagonize with Nrf2 and promotes the terminal differentiation of megakaryocytes resulting in the increase of intracellular reactive oxygen species. I also found that NF-E2 p45 directly activates the genes encoding the factors involved in the platelet function. In tumor-bearing mice, expression of NF-E2 p45 and its target genes was robustly increased