Analysis of the alteration of signal pathway in soft tissue sarcoma

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We demonstrated the activation of Akt-mTOR pathway in leiomyosarcoma, synovial sarcoma, malignant peripheral nerve sheath tumor, myxofibrosarcoma, solitary fibrous tumor and dermatofibrosarcoma protuberans. Activation of this pathway was correlated with histopathological malignancy and poor prognosis in these tumors. Therefore, Akt-mTOR pathway may be the candidate of molecular target in these non-small round cell sarcomas