Molecular basis for the functional regulation of intractable inflammatory disorders by Osteopontin

在经典的细胞外基质蛋白（ECM）中有一组独特的分子。这些分子应该被称为基质细胞蛋白，我们证明了这些蛋白参与了各种顽固性炎症疾病的发病机制，包括类风湿关节炎和多发性硬化症。骨桥蛋白（OPN）和腱蛋白c （TN-C）是两个例子，它们具有共同的受体，α 9beta1整合素，并通过该整合素受体传导细胞内信号。重要的是，我们发现OPN、TN-C和alpha9beta1整合素是多种炎症性疾病的治疗靶点，针对OPN、TN-C和alpha9beta1整合素的阻断单克隆抗体可能是未来的治疗性抗体药物。

There is a distinct group of molecules within classical extracellular matrix proteins (ECM). These molecules should be called as matricellular proteins and we demonstrated that these proteins are involved in the pathogenesis of various intractable inflammatory disorders including rheumatoid arthritis and multiple sclerosis. Osteopontin (OPN) and tenascin-C (TN-C) are two examples and share common receptor, alpha9beta1 integrin and transducer intracellular signaling via this integrin receptor. Importantly, we found that OPN, TN-C and alpha9beta1 integrin are therapeutic targets in various inflammatory diseases and blocking monoclonal antibodies against OPN, TN-C and alpha9beta1 integrin can be future therapeutic antibody drugs.