Development of Redox Controlling Nanomedicine Based on Albumin Fusion
Development of Redox Controlling Nanomedicine Based on Albumin Fusion
批准号:
21390177
负责人:
OTAGIRI Masaki
金额:
$12.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Using albumin fusion technology, a novel redox controlling nanomedicine was designed and evaluated for applications in clinical settings. The results from various studies suggested that HSA-thioredoxin fusion protein has great potential as a therapeutic agent for treating oxidative stress and inflammation related diseases. In addition, a significant tumor metastasis activity from the EPR effect of SNO-HSA dimer has been confirmed. Based on the results of the current studies, preparations for a clinical trial led by a clinician are now in progress.
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プレオマイシン誘発肺線維症に対するアルブミン-チオレドキシン融合体の有用性評価
白蛋白-硫氧还蛋白融合物对抗多霉素诱导的肺纤维化有效性的评估
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[田中遼大, 古川真斗, 異島優, 田中健一郎, 水島徹, 渡邊博志, 小田切優樹, 丸山徹]
通讯作者:
丸山徹
ファージディスプレイ法を用いたHSA分子上のBR結合部位の探索
使用噬菌体展示法搜索 HSA 分子上的 BR 结合位点
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[蓑毛藍、小田切優樹, 他]
通讯作者:
他
α_1-酸性糖タンパク質はS-ニトロソ化により抗菌活性を獲得する
α_1-酸性糖蛋白通过S-亚硝化获得抗菌活性
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[渡辺佳織, 異島優, 末永綾香, 渡邊博志, 甲斐俊哉, 丸山徹, 小田切優樹]
通讯作者:
小田切優樹
一酸化炭素を付加した赤血球は大量出血時における肝チトクロームP450を保護する
负载一氧化碳的红细胞在大出血期间保护肝细胞色素 P450
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大柿滋, 田口和明, 渡邉博志, 小田切優樹, 丸山徹]
通讯作者:
丸山徹
REACTIVE ALDEHYDES INDUCE STRUCTUAL CHANGE AND DISFUNCTION OF HUMAN SERUM ALBUMIN
活性醛引起人血清白蛋白的结构变化和功能丧失
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Inoue K, et al., Takeo K]
通讯作者:
Takeo K
共 137 条
Development of novel hybrid anti-oxidant based on albumin fusion technology and its therapeutic application on acute radiation syndrome
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批准号:15K15008
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
-
财政年份:2015
-
负责人:OTAGIRI Masaki
-
依托单位:
Construction of an Innovative Bone Marrow Delivery System of Anticancer Drug for Control of Malignant Tumors' Bone Metastasis
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批准号:25670085
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2013
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负责人:OTAGIRI Masaki
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依托单位:
Design and Evaluation of Next Generation Albumin-thioredoxin Fusion Protein for Multiple Organ Failure Treatment
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批准号:24390043
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
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财政年份:2012
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负责人:OTAGIRI Masaki
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依托单位:
Development of effective blood purification treatment method usingHSA bound toxic comnpodus designed bpyhase display tecnohlogy
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批准号:23659088
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:OTAGIRI Masaki
-
依托单位:
Application of functional recombinant HSAs as a DDS carrier
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批准号:18390051
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.09万
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财政年份:2006
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负责人:OTAGIRI Masaki
-
依托单位:
The development of next-generation albumin preparation by mutagenesi s studies
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批准号:14370759
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.58万
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财政年份:2002
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负责人:OTAGIRI Masaki
-
依托单位:
Design and Evaluation of Albumin Mutants for Clinical Application
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批准号:11694298
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项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$4.67万
-
财政年份:1999
-
负责人:OTAGIRI Masaki
-
依托单位:
Design and Functional Evaluation of Albumin Mutants for Improving Medicinal Efficacy
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批准号:10557245
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项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$6.85万
-
财政年份:1998
-
负责人:OTAGIRI Masaki
-
依托单位:
Topology Analysis of Drug Binding Sites on Serum Proteins using Photoaffinity Labeling Techniques
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批准号:09470505
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.17万
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财政年份:1997
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负责人:OTAGIRI Masaki
-
依托单位:
Development of Pharmaceutical Additives-Evaluation of Protein and Polysaccharide Hydrolysates as Carrier to Enhance Absorption Rate of Drug
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批准号:07557146
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.37万
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财政年份:1995
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负责人:OTAGIRI Masaki
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依托单位:
Microenviromental Analysis of Drug Binding Site on Albumin by Point-mutation and Using Probe
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批准号:06672146
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.54万
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财政年份:1994
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负责人:OTAGIRI Masaki
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依托单位:
Microenvironmental Analysis of Drug Binding Sites on Human Serum Albumin and alpha_1-Acid Glycoprotein
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批准号:02807196
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.02万
-
财政年份:1990
-
负责人:OTAGIRI Masaki
-
依托单位:
海外基金