Development of effective blood purification treatment method usingHSA bound toxic comnpodus designed bpyhase display tecnohlogy

点击翻译按钮获取中文摘要

This study was undertaken to design and evaluate recombinant albumin mutant( specially, domain II mutant)with high bilirubin (BR) binding affinity via phage display technology.The results obtained here identified the amino acid residues that interact carboxylatesof BR in HSA, and also produces HSA domain II mutants with high BR binding affinity. To our knowledge, this is the first finding on HSA mutant with enhanced binding affinity to BR. This approach could be applied to other HSA bound toxic compounds that responsible for the progression oifseadse and thereby it will pave the way for the development ofminimally invasive and low cost blood clarification method.