Elucidation of roles of essential trace metals in higher nervous activity

阐明必需微量金属在高级神经活动中的作用

• 批准号: 21390185
• 负责人: SAITO Takeshi
• 金额: $ 11.56万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390185/
• 关键词: 微量金属; 金属イオン膜輸送蛋白; 中枢神経系; 神経伝達物質; 老化; メタロシャペロン; 脳機能

The aim of this study is to elucidate roles of trace elements, metal transporters and metallochaperone in the central nervous system. Our results indicate that reduction of Cu transporter Ctr1 but not MT induction is the primary cause of the inhibition of Cu absorption by excessive intake of Zn. Declines of syntheses of catecholamines and zinc concentrations were observed in the cerebral cortex of SAMP10 with aging. Cu-polyphenol induces apoptosis via CCS-XIAP degradation induced by incorporated Cu in PC12 cells

本研究旨在阐明微量元素、金属转运蛋白和金属伴侣在中枢神经系统中的作用。我们的研究结果表明，铜转运蛋白Ctr 1的减少，而不是MT诱导是抑制铜吸收过量摄入锌的主要原因。随着年龄的增长，SAMP 10小鼠大脑皮层中的锌含量和儿茶酚胺的合成量均呈下降趋势。Cu-多酚通过诱导CCS-XIAP降解诱导PC 12细胞凋亡

项目成果

Comparison of general water quality of rivers in Indonesia and Japan

• DOI: 10.1007/s10661-008-0487-z
• 发表时间: 2009-09-01
• 期刊: ENVIRONMENTAL MONITORING AND ASSESSMENT
• 影响因子: 3
• 作者: Kido, Machiko;Yustiawati;Kurasaki, Masaaki
• 通讯作者: Kurasaki, Masaaki

クルクミン・銅および同時添加により引き起こされる細胞死とその機構

姜黄素、铜同时添加引起的细胞死亡及其机制

• 发表时间: 2009
• 作者: Yataro Daigo;Yusuke Nakamura;掛山正心・遠山千春;佐藤睦将
• 通讯作者: 佐藤睦将

Elucidation of the role of zinc, zinc-enzyme and tetrahydrobiopterin in the alteration of chatecholamine metabolism in the cerebral cortex with aging in senescence-accelerated mouse

阐明锌、锌酶和四氢生物蝶呤在加速衰老小鼠大脑皮层儿茶酚胺代谢变化中的作用

• 发表时间: 2011
• 作者: Mady FM;Abou-Taleb AE;Khaled KA;Yamasaki K;Iohara D;Taguchi K;Anraku M;Hirayama F;Uekama K;Otagiri M.;掛山正心;Miyajima M et al.
• 通讯作者: Miyajima M et al.

Mechanism of toxicity on human vascular endothelial cells by humic acid obtained from tropical peatland

热带泥炭地腐殖酸对人体血管内皮细胞的毒性机制

• 发表时间: 2011
• 作者: Kihara;Y et al.
• 通讯作者: Y et al.

Dysfunction of neurogenic VIP-mediated relaxation in mouse distal colon with dextran sulfate sodium-induced colitis

右旋糖酐硫酸钠诱导的小鼠远端结肠神经源性 VIP 介导的舒张功能障碍

• 发表时间: 2012
• 期刊: Pharmacological Research
• 影响因子: 9.3
• 作者: Kato E.;Yamane S.;Nomura R.;Matsumoto K;Tashima K.;Horie S.;Saito T.;Fujino H.;Murayama T.
• 通讯作者: Murayama T.