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Development of evaluation methods for effects of environmental chemicals on the central nervous systems

Development of evaluation methods for effects of environmental chemicals on the central nervous systems
环境化学物质对中枢神经系统影响评价方法的开发
批准号:
22659120
负责人:
SAITO Takeshi
金额:
$2.07万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We developed evaluation methods for effects of environmental chemicals on the central nervous systems. First of all, the method for the quantification of DNA damage by chemicals in tissues and cultured cells was developed. Using the method, we evaluated apoptotic effects of diethyl phthalate parabens and a stevioside. Secondly, we developed an evaluation method for effects of chemicals on cell differentiation in PC12 cells. In addition, the evaluation method to detect apoptosis induced by metals and chelated metals was developed.
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Diethyl phthalate enhances apoptosis induced by serum deprivation inPC12 cells
邻苯二甲酸二乙酯增强 PC12 细胞血清剥夺诱导的细胞凋亡
DOI: 10.1111/j.1742-7843.2012.00869.x
发表时间: 2012
期刊: Basic & Clinical Pharmacology& Toxicology
影响因子: --
作者: [Sun Y, Takahashi K, Saito T, Hosokawa T, Kurasaki M]
通讯作者: Kurasaki M
Effect ofquercetin intake during lactation on the AMPK activation in the hypothalamus of adult male rat offspring programmed by maternal protein restriction
哺乳期槲皮素摄入对母体蛋白质限制的成年雄性大鼠后代下丘脑 AMPK 激活的影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Md. Tajuddin Sikder et al, Yongkun Sun et al, 押谷仁, Masato Tanaka et al]
通讯作者: Masato Tanaka et al
Effects of parabens on apoptosis induced by serum-free medium
对羟基苯甲酸酯对无血清培养基诱导细胞凋亡的影响
DOI: 10.1080/03601234.2012.634341
发表时间: 2012
期刊: Journal of Environmental Science and Health
影响因子: --
作者: [Egawa M, Aoki K, Sun Y, Hosokawa T, Saito T and Kurasaki M]
通讯作者: Saito T and Kurasaki M
Stevioside enhances apoptosis induced by serum deprivation in PC12 cells
甜菊苷增强 PC12 细胞血清剥夺诱导的细胞凋亡
DOI: 10.3109/15376516.2012.658978
发表时间: 2012
期刊: Toxicology Mechanisms and Methods
影响因子: 3.2
作者: [Takahashi K, Sun Y, Yanagiuchi I, Hosokawa T, Saito T, Komori M, Okino T and Kurasaki M]
通讯作者: Okino T and Kurasaki M
25
    Construction of basic data in toxicological evaluation: single and drug combinations used whole blood
    • 批准号:
      17K09278
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2017
    • 负责人:
      SAITO Takeshi
    • 依托单位:
    Quantitative evaluation of effect of subsurface warming on production and consumption of greenhouse gases
    • 批准号:
      26889015
    • 项目类别:
      Grant-in-Aid for Research Activity Start-up
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      $1.75万
    • 财政年份:
      2014
    • 负责人:
      SAITO Takeshi
    • 依托单位:
    Simultaneous determination of aconitines, amanitin, and tetrodotoxin using LC-MSMS
    • 批准号:
      25460878
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2013
    • 负责人:
      SAITO Takeshi
    • 依托单位:
    Eruption processes inferred from magnetic petrology of FeTi oxides
    • 批准号:
      25870290
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2013
    • 负责人:
      SAITO Takeshi
    • 依托单位:
    海外基金