Cancer prevention study on the relationship of cancer stem cells biomarker and 8-nitroguanine in cancer tissues
癌组织中癌干细胞生物标志物与8-硝基鸟嘌呤关系的防癌研究
基本信息
- 批准号:21390195
- 负责人:
- 金额:$ 11.56万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2009
- 资助国家:日本
- 起止时间:2009 至 2011
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
8-Nitroguanine was formed in Oct3/4-positive stem cells in S. haematobium-associated cystitis and cancer tissues. 8-Nitroguanine and stem cell marker glypican-3 was observed in Barrett's esophagus tissues. In conclusion, inflammation by various facters may increase the number of mutant stem cells, in which nitrative DNA damage occurs, leading to tumor development.
8-在S.与血液相关的膀胱炎和癌组织。8-在Barrett食管组织中观察到硝基鸟嘌呤和干细胞标志物磷脂酰肌醇蛋白聚糖-3。总之,各种因素引起的炎症可能会增加突变干细胞的数量,其中发生硝化DNA损伤,导致肿瘤的发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Role of iNOS-Mediated DNA Damage in Inflammation-Related Care inogenesis
iNOS 介导的 DNA 损伤在炎症相关护理发生中的作用
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:S. Kawanishi;S. Ohnishi;H. Saito;N. Suzuki;Y. Hiraku;M. Murata;Kawanishi S.;Hiraku Y.
- 通讯作者:Hiraku Y.
炎症・再生医学事典
炎症与再生医学百科全书
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:Li Y-Y;Wu Y;Tsuneyama K;Baba T;Mukaida N.;吉崎真理子;森本純子
- 通讯作者:森本純子
寄生虫感染による幹様細胞における酸化・ニトロ化DNA損傷
寄生虫感染导致干细胞样细胞氧化和硝化 DNA 损伤
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Thanan Raynoo
- 通讯作者:Thanan Raynoo
Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer.
- DOI:10.1155/2012/165879
- 发表时间:2012
- 期刊:
- 影响因子:4.6
- 作者:Thanan R;Murata M;Ma N;Hammam O;Wishahi M;El Leithy T;Hiraku Y;Oikawa S;Kawanishi S
- 通讯作者:Kawanishi S
DNA damage and estrogenic activity induced by the environmental pollutant 2-nitrotoluene and its metabolite
- DOI:10.1007/s12199-010-0146-1
- 发表时间:2010-04
- 期刊:
- 影响因子:4.7
- 作者:C. Watanabe;Takashi Egami;K. Midorikawa;Y. Hiraku;S. Oikawa;S. Kawanishi;M. Murata
- 通讯作者:C. Watanabe;Takashi Egami;K. Midorikawa;Y. Hiraku;S. Oikawa;S. Kawanishi;M. Murata
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KAWANISHI Shosuke其他文献
KAWANISHI Shosuke的其他文献
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{{ truncateString('KAWANISHI Shosuke', 18)}}的其他基金
Molecular epidemiological study on cholangio-carcinogenesis induced by liver fluke Opisthorchis viverrini in Thailand.
泰国肝吸虫 Opisthorchis viverrini 诱发胆管癌的分子流行病学研究。
- 批准号:
21406019 - 财政年份:2009
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of the biomarker analysis system for evaluating the risk of carcinogenesis related to infection and inflammation
开发用于评估与感染和炎症相关的致癌风险的生物标志物分析系统
- 批准号:
18390179 - 财政年份:2006
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The mechanism for the formation of hotspots in relation to evaluation of carcinogenic risks of environmental chemicals
环境化学物质致癌风险评价热点形成机制
- 批准号:
15390187 - 财政年份:2003
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular epidemiological study on the pathogenesis of cholangiocarcinoma caused by infection with liver flukes in Thailand
泰国肝吸虫感染所致胆管癌发病机制的分子流行病学研究
- 批准号:
15406027 - 财政年份:2003
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of evaluation system for cancer chemopreventive agents based on DNA damage inhibition and gene expression
基于DNA损伤抑制和基因表达的癌症化学预防剂评价体系的开发
- 批准号:
13557030 - 财政年份:2001
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of sequence-specific DNA damage by oxidative stress and prevention of cancer and aging
分析氧化应激造成的序列特异性 DNA 损伤以及预防癌症和衰老
- 批准号:
12470084 - 财政年份:2000
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Evaluation of toxicity of environmental chemicals on the basis of their estrogenic activity and DNA-damaging ability and regional risk assessment
基于雌激素活性和DNA损伤能力的环境化学品毒性评价和区域风险评估
- 批准号:
11794019 - 财政年份:1999
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for University and Society Collaboration
The method of safety evaluation of chemopreventive agents based on the ability of damaging human genes
基于破坏人体基因能力的化学预防剂安全性评价方法
- 批准号:
10557040 - 财政年份:1998
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Mechanisms of DNA damage induced by environmental factors and cancer chemoprevention
环境因素诱导的DNA损伤机制与癌症化学预防
- 批准号:
09470101 - 财政年份:1997
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Oxygen radical formation and DNA damage induced by metal compounds in relation to carcinogenicity
金属化合物诱导的氧自由基形成和 DNA 损伤与致癌性的关系
- 批准号:
06454227 - 财政年份:1994
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)