Molecular epidemiological study on cholangio-carcinogenesis induced by liver fluke Opisthorchis viverrini in Thailand.
Molecular epidemiological study on cholangio-carcinogenesis induced by liver fluke Opisthorchis viverrini in Thailand.
批准号:
21406019
负责人:
KAWANISHI Shosuke
金额:
$11.32万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
胆管癌(CCA)与肝吸虫感染引起的慢性炎症有关。干细胞标记物(CD133、OV6、CK-19)和DNA碱基损伤(8-oxodG、8-硝基鸟嘌呤)在CCA中明显共定位。我们在CCA组织中鉴定了14种高度羰基化的蛋白。这些蛋白的氧化修饰与Kaplan-Meier法确定的不良预后显著相关。
英文摘要
Cholangiocarcinoma(CCA) is associated with chronic inflammation caused by liver fluke infection. Stem cell markers(CD133, OV6, CK-19) and DNA base damage(8-oxodG, 8-nitroguanine) were clearly colocalized in CCA. We identified 14 highly carbonylated proteins in CCA tissues. The oxidative modification of these proteins was significantly associated with poor prognoses as determined by the Kaplan-Meier method.
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DOI:
10.1155/2012/165879
发表时间:
2012
期刊:
Mediators of inflammation
影响因子:
4.6
作者:
[Thanan R, Murata M, Ma N, Hammam O, Wishahi M, El Leithy T, Hiraku Y, Oikawa S, Kawanishi S]
通讯作者:
Kawanishi S
DOI:
10.1007/s12199-010-0146-1
发表时间:
2010-04
期刊:
Environmental Health and Preventive Medicine
影响因子:
4.7
作者:
[C. Watanabe;Takashi Egami;K. Midorikawa;Y. Hiraku;S. Oikawa;S. Kawanishi;M. Murata]
通讯作者:
C. Watanabe;Takashi Egami;K. Midorikawa;Y. Hiraku;S. Oikawa;S. Kawanishi;M. Murata
Nitrative and oxidative DNA damage caused by K-ras mutation in mice
K-ras突变引起小鼠的硝基和氧化DNA损伤
DOI:
10.1016/j.bbrc.2011.08.076
发表时间:
2011
期刊:
Biochem.Biophys.Res.Commun.
影响因子:
--
作者:
[Ohnishi, S.]
通讯作者:
S.
DOI:
10.1111/j.1749-6632.2010.05602.x
发表时间:
2010-01-01
期刊:
OXIDATIVE/NITROSATIVE STRESS AND DISEASE
影响因子:
--
作者:
[Hiraku, Yusuke, Kawanishi, Shosuke, Murata, Mariko]
通讯作者:
Murata, Mariko
上咽頭がんにおけるゲノムワイドなメチル化DNAの解析
鼻咽癌甲基化DNA的全基因组分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Mo Yingxi]
通讯作者:
Mo Yingxi
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