Molecular epidemiological study on cholangio-carcinogenesis induced by liver fluke Opisthorchis viverrini in Thailand.

泰国肝吸虫 Opisthorchis viverrini 诱发胆管癌的分子流行病学研究。

• 批准号: 21406019
• 负责人: KAWANISHI Shosuke
• 金额: $ 11.32万
• 依托单位: Suzuka University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21406019/
• 关键词: DNA損傷; 感染; 炎症; がん予防; 酸化ストレス; 胆管癌; 肝吸虫; 8-ニトログアニン

Cholangiocarcinoma(CCA) is associated with chronic inflammation caused by liver fluke infection. Stem cell markers(CD133, OV6, CK-19) and DNA base damage(8-oxodG, 8-nitroguanine) were clearly colocalized in CCA. We identified 14 highly carbonylated proteins in CCA tissues. The oxidative modification of these proteins was significantly associated with poor prognoses as determined by the Kaplan-Meier method.

胆管癌（CCA）与肝吸虫感染引起的慢性炎症有关。干细胞标志物（CD 133、OV 6、CK-19）和DNA碱基损伤（8-oxodG、8-硝基鸟嘌呤）在CCA中明显共定位。我们在CCA组织中鉴定了14种高度羰基化的蛋白质。这些蛋白质的氧化修饰与Kaplan-Meier法测定的不良代谢显著相关。

项目成果

Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer.

• DOI: 10.1155/2012/165879
• 发表时间: 2012
• 期刊: Mediators of inflammation
• 影响因子: 4.6
• 作者: Thanan R;Murata M;Ma N;Hammam O;Wishahi M;El Leithy T;Hiraku Y;Oikawa S;Kawanishi S
• 通讯作者: Kawanishi S

DNA damage and estrogenic activity induced by the environmental pollutant 2-nitrotoluene and its metabolite

• DOI: 10.1007/s12199-010-0146-1
• 发表时间: 2010-04
• 期刊: Environmental Health and Preventive Medicine
• 影响因子: 4.7
• 作者: C. Watanabe;Takashi Egami;K. Midorikawa;Y. Hiraku;S. Oikawa;S. Kawanishi;M. Murata

Nitrative and oxidative DNA damage caused by K-ras mutation in mice

K-ras突变引起小鼠的硝基和氧化DNA损伤

• DOI: 10.1016/j.bbrc.2011.08.076
• 发表时间: 2011
• 期刊: Biochem.Biophys.Res.Commun.
• 作者: Ohnishi;S.
• 通讯作者: S.

The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis

• DOI: 10.1111/j.1749-6632.2010.05602.x
• 发表时间: 2010-01-01
• 期刊: OXIDATIVE/NITROSATIVE STRESS AND DISEASE
• 作者: Hiraku, Yusuke;Kawanishi, Shosuke;Murata, Mariko
• 通讯作者: Murata, Mariko

上咽頭がんにおけるゲノムワイドなメチル化DNAの解析

鼻咽癌甲基化DNA的全基因组分析

• 发表时间: 2011
• 作者: Mo Yingxi