Research on the fetal origin of adult disease hypothesis using large scale longitudinal twin-family data

利用大规模纵向双胞胎家庭数据研究成人疾病胎儿起源假说

• 批准号: 21390206
• 负责人: OOKI Syuichi
• 金额: $ 9.9万
• 依托单位: Ishikawa Prefectural Nursing University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390206/
• 关键词: 双生児; 縦断データ; 胎内環境仮説; 生殖補助医療; 生活習慣病; 遺伝疫学; ライフコース; データベース; 出生体重; 長期縦断データ

Fetal Origins of Adult Disease(FOAD) hypothesis was studied using twin sample. Longitudinal twin database from perinatal to adult period was constructed. Next, preliminary genetic epidemiologic analyses were conducted. The influence of assisted reproductive technology and laterality were also analyzed as candidate new marker of perinatal and early life environment. It was suggested that FOAD hypothesis is not necessarily applicable in the same manner as singletons in twins. The reason was not clear whether the problem was based on the weakness of the statistic power or adoption mechanism specific to twins.

采用双生子样本研究了胎儿起源于成人疾病（FOAD）假说。建立从围产期到成年期的纵向双生子数据库。接下来，进行了初步的遗传流行病学分析。辅助生殖技术的影响和偏侧性作为围产期和早期生活环境的候选新标志进行了分析。有人认为，FOAD假设并不一定像双胞胎中的单胞胎一样适用。原因尚不清楚，这个问题是基于统计力量的弱点还是双胞胎特有的采用机制。

项目成果

Estimation of the contribution of assisted and non-assisted reproductive technology fertility treatments to multiple births during the last thirty years in Japan: 1977-2008

过去三十年日本辅助和非辅助生殖技术生育治疗对多胞胎的贡献估计：1977-2008

• 发表时间: 2012
• 作者: 佐野浩斎;西村理明;志田樹理;風巻真理子;安藤精貴;辻野大助;瀧謙太郎;石川眞一郎;田嶼尚子;宇都宮一典;Mika Oki;Masashi Otai;Syuichi Ooki
• 通讯作者: Syuichi Ooki

Theoretical Model of the Relationship between Single Embryo TVansfer Rate and Multiple Pregnancy Rate in Japan

日本单胚胎移植率与多胎妊娠率关系的理论模型

• 发表时间: 2012
• 期刊: Journal of Pregnancy
• 影响因子: 3.2
• 作者: Hirose T;Imai Y;et al;Syuichi Ooki
• 通讯作者: Syuichi Ooki

Strategy and Practice of Support for Families with Multiple Births Children : Combination of Evidence-Based Public Health (EBPH) and Community-Based Participatory Research (CBPR) Aproach.(In : Public Health-Social and Behavioral Health)(Maddock J (ed))

支持多胞胎家庭的策略和实践：基于证据的公共卫生 (EBPH) 和基于社区的参与性研究 (CBPR) 方法的结合。（在：公共卫生-社会和行为健康）（Maddock J（ed）

• 发表时间: 2012
• 作者: Syuichi Ooki;Kiyomi Hiko(共著)
• 通讯作者: Kiyomi Hiko(共著)

Strategy and Practice of Support for Families with Multiple Births Children : Combination of Evidence-Based Public Health(EBPH) and Community-Based Participatory Research(CBPR) Approach

支持多胞胎家庭的策略与实践：循证公共卫生（EBPH）和社区参与研究（CBPR）方法的结合

• 发表时间: 2012
• 作者: Syuichi Ooki;Kiyomi Hiko;Maddock J
• 通讯作者: Maddock J

Human Handedness in Twins: An Overview

双胞胎中的人类惯用手：概述

• 发表时间: 2012
• 作者: Oki M;Sunahara T;Hashizume M;Yamamoto T.;大木秀一;Syuichi Ooki
• 通讯作者: Syuichi Ooki