Identification of host genes responsible for the treatment response of interferon therapy for the patients with chronic hepatitis C

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This study demonstrated that the induction of interferon stimulated genes(ISGs) was closely related to the treatment response to IFN therapy. Up-regulated ISGs expression of in liver before treatment might impair the de novo ISGs induction in liver. Interestingly, up-regulated ISGs in liver before treatment were closely related to IL28 minor genotype. Therefore, Il28B genotype must be involved in different ISGs induction in liver. There was a significant correlation of ISGs expression between the liver and PBMC in patients with IL28B major genotype, while no correlation was found in patients with IL28B minor genotype. Detailed examination of liver biopsy specimen by laser capture micro dissection revealed the impaired infiltration of immune cells in liver lobules in patients with IL28B minor genotype. These immune regulatory imbalances of IL28B minor genotype might contribute to the poor response to IFN therapy