Research for the elucidation of the cardiovascular effect and application to treatment by adenosine

阐明腺苷心血管作用及其在治疗中的应用的研究

• 批准号: 21390251
• 负责人: KITAKAZE Masafumi
• 金额: $ 11.48万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390251/
• 关键词: アデノシン; 心不全診断; 心不全治療; トランスレーショナル研究; 臨床試験

Adenosine is known to be a key regulatory molecule of cardioprotection. However, it has been difficult to demonstrate the molecular mechanisms for the cardiovascular protective mechanisms of adenosine. To solve this question, we have firstly established the highly-sensitive system of the measurements of plasma adenosine level using LC-MS. Secondly, we demonstrated the multiple cardiovascular protective mechanisms of adenosine in a variety of the pathophysiological condition by the measurement of adenosine levels in the blood and myocardial tissue samples. Moreover, the clarification of the alteration in gene expression levels in patients with heart failure implied that adenosine-related gene expression might modulate the pathophysiology of heart failure, and the addition of adenosine is a candidate for the treatment of heart failure. Fourthly, we showed that the plasma adenosine levels can be a marker of the severity of heart failure in the clinical study. Taken together, we need to focus on the adenosine metabolism in the pathophysiology of cardiovascular diseases via the present study.

腺苷被认为是心脏保护的关键调节分子。然而，它一直难以证明腺苷的心血管保护机制的分子机制。为了解决这一问题，我们首先建立了高灵敏度的血浆腺苷水平的LC-MS测定系统。其次，我们通过测定血液和心肌组织样品中的腺苷水平，证明了腺苷在各种病理生理条件下的多种心血管保护机制。此外，心力衰竭患者基因表达水平改变的澄清表明腺苷相关基因表达可能调节心力衰竭的病理生理学，并且腺苷的添加是治疗心力衰竭的候选药物。第四，我们在临床研究中发现，血浆腺苷水平可以作为心力衰竭严重程度的标志。总之，我们需要关注腺苷代谢在心血管疾病的病理生理通过本研究。

项目成果

Familial bradycardia caused by the mutation of inward rectifier potassium channel

内向整流钾通道突变引起的家族性心动过缓

• 发表时间: 2010
• 作者: Takashima S;Asano Y;Fujita M;Minamino T;Komuro I;Kitakaze M
• 通讯作者: Kitakaze M

Medicina-心不全の治療 薬物療法 ニコランジルを中心に

医学-心力衰竭的治疗 药物治疗 聚焦尼可地尔

• 发表时间: 2009
• 作者: 朝倉正紀;北風政史
• 通讯作者: 北風政史

Cardioprotective effects of low-dose combination therapy with a statin and an angiotensin receptor blocker in a rat myocardial infarction model.

• DOI: 10.1016/j.jjcc.2011.07.013
• 发表时间: 2012
• 期刊: Journal of cardiology
• 影响因子: 2.5
• 作者: Ryoichi Sohma;Teruo Inoue;S. Abe;I. Taguchi;M. Kikuchi;Shigeru Toyoda;Takuo Arikawa;Y. Hikichi;S. Sanada;H. Asanuma;M. Kitakaze;K. Node

A novel approach using exon array technique identifies Mtus1 as a new heart failure-related gene

使用外显子阵列技术的新方法将 Mtus1 鉴定为新的心力衰竭相关基因

• 发表时间: 2011
• 作者: Ito S.;et al
• 通讯作者: et al

冠血流の生理学と虚血カラー版循環器病学

冠状动脉血流和缺血的生理学彩色版心脏病学

• 发表时间: 2010
• 作者: 浅沼博司;北風政史
• 通讯作者: 北風政史