Exploration of virulence factors, investigation of clinical pathophysiology, and construction of database for cryptococcosis

隐球菌病毒力因子探索、临床病理生理学研究及数据库构建

• 批准号: 21390305
• 负责人: KOHNO Shigeru
• 金额: $ 11.23万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390305/
• 关键词: 感染疫学; クリプトコックス; クリプトコックス症; 病原因子; 臨床データベース; gDNA; genotype; 血清型; RNA

Cryptococcus species isolated from non-HIV patients with cryptococcosis were investigated. However, no apparent relevance was detected between genotype variations (VNI or VNII) and clinical manifestations. Retrospective review of 151 patients with proven pulmonary cryptococcosis.There were 67 cases (44.4%) in immunocompetent hosts. Eighty-four patients (65.6%) had underlying disease. The most common were diabetes (32.1%), hematologic disease (22.6%), and collagen disease.Peripherally distributed pulmonary nodules/masses were most commonly seen in both groups. Lesions in the right middle lobe and air bronchogram were significantly more frequent (p = 0.01 and p = 0.05), respectively, in immunocompromised hosts than immunocompetent hosts. Azole-type drugs were mainly selected to treat pulmonary cryptococcosis patients without encephalomeningitis. Mean treatment duration for immunocompetent and immunocompromised patients was 2.87 months and 6.64 months, respectively.

隐球菌属物种从非HIV隐球菌病患者分离进行了调查。然而，基因型变异（VNI或VNII）与临床表现之间没有明显的相关性。 回顾性分析151例肺隐球菌病的临床资料，其中67例（44.4%）为免疫功能正常的宿主。84例患者（65.6%）有基础疾病。最常见的是糖尿病（32.1%）、血液病（22.6%）和胶原病，两组中最常见的是周围分布的肺结节/肿块。在免疫功能低下的宿主中，右中叶病变和支气管充气征的发生率分别显著高于免疫功能正常的宿主（p = 0.01和p = 0.05）。唑类药物主要用于治疗无脑膜炎的肺隐球菌病。免疫功能正常和免疫功能低下患者的平均治疗持续时间分别为2.87个月和6.64个月。

项目成果

Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata.

• DOI: 10.1371/journal.ppat.1003160
• 发表时间: 2013-01
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Miyazaki T;Nakayama H;Nagayoshi Y;Kakeya H;Kohno S
• 通讯作者: Kohno S

真菌の抗真菌薬耐性の現状と治療戦略

真菌抗真菌药物耐药现状及治疗策略

• 发表时间: 2012
• 作者: 泉川公一;河野 茂
• 通讯作者: 河野 茂

肺炎の克服を目指して

力争战胜肺炎

• 发表时间: 2013
• 作者: Eto T;Choi I;Tanosaki R;Takatsuka Y;Utsunomiya A;Takemoto S;Taguchi J;Fukushima T;Kato K;Teshima T;Suehiro Y;Yamanaka T;Okamura J;Uike N;河野茂
• 通讯作者: 河野茂

ガイドラインサポートブックIDSA GL:真菌症治療のUP-TO-DAIE～2008～2010年のアスペルギルス、カンジダ、クリプトコックスIDSA GL改訂版を踏まえて～

指南支持手册 IDSA GL：真菌病治疗的 UP-TO-DAIE ~基于 2008-2010 年曲霉、念珠菌和隐球菌 IDSA GL 修订版~

• 发表时间: 2010
• 作者: 芹川忠夫;大守伊織;大内田守;大野行弘;鶴見東志子;三木崇史;若森実;石原靜;吉田卓史;滝沢明子;加藤めぐみ;平林真澄;笹征史;森泰生;真下知士;Urabe M;西小森隆太;河野茂(編集)
• 通讯作者: 河野茂(編集)

A case series of chronic necrotizing pulmonary aspergillosis and a new proposal

慢性坏死性肺曲霉病病例系列及新建议

• 发表时间: 2013
• 期刊: Jpn J Infect Dis
• 影响因子: 2.2
• 作者: Tashiro T;Izumikawa K;Tashiro M;Morinaga Y;Nakamura S;Imamura Y;Miyazaki T;Kakeya H;Yamamoto Y;Yanagihara K;Hayashi T;Nagayasu T;Kohno S
• 通讯作者: Kohno S