Investigation of clinical significance of lymph node micro metastasis in gastro intestinal cancer.

胃肠癌淋巴结微转移的临床意义探讨

• 批准号: 21390382
• 负责人: NATSUGOE Shoji
• 金额: $ 10.73万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390382/
• 关键词: リンパ節転移; 微小転移; サイトケラチン染色; RT-PCR; Gene Search System; センチネルリンパ節; ケモカイン; リンパ管新生; CEA; Sentinel node navigation surgery; Gene Search system; mammalobin; 血管新生

In the clinical significance of lymph node micrometastasis(LMM), LMM was examined by immunostaining and RT-PCR. The diagnosis of LMM is clinically useful for less invasive surgery such as sentinel node navigation surgery. Some genes related with lymph node metastasis were found by microaaray method. Such genes correlated well with clinical samples of gastrointestinal cancer. Preoperative chemo-radiation therapy was effective for LMM in esophageal cancer. The factors of lymphangiogenesis and chemokines were important for the formation and growth of LMM. In experimental study, a few cancer cells had growth ability and such result may offer important information for cancer treatment.

在淋巴结微转移（LMM）的临床意义上，采用免疫染色和RT-PCR检测LMM。LMM的诊断对前哨淋巴结导航手术等微创手术具有临床价值。微放射法发现了一些与淋巴结转移相关的基因。这些基因与胃肠道癌症的临床样本有很好的相关性。术前放化疗对食管癌LMM有效。淋巴管生成因子和趋化因子对LMM的形成和生长起重要作用。在实验研究中，少数癌细胞具有生长能力，这一结果可能为癌症治疗提供重要信息。

项目成果

Neoadjuvant chemoradiotherapy for advanced esophageal cancer

晚期食管癌的新辅助放化疗

• 发表时间: 2011
• 期刊: Nihon Geka Gakkai Zasshi
• 作者: Imanishi Y;Miyagawa S;Saito A;Sawa Y;Natsugoe S.
• 通讯作者: Natsugoe S.

Clinical Significance of Stanniocalcin 2 expression in esophageal squamous cell carcinoma : Identification of lymph node metastasis-specific genes using oligonucleotide microarray.

食管鳞状细胞癌中斯钙素 2 表达的临床意义：使用寡核苷酸微阵列鉴定淋巴结转移特异性基因。

• 发表时间: 2010
• 作者: Kita Y;Natsugoe S;et al.
• 通讯作者: et al.

Salem sump tube is regarded as a useful chest drain

塞勒姆污水管被认为是有用的胸腔引流管

• 发表时间: 2009
• 作者: Yanagi M;Natsugoe S;et al.
• 通讯作者: et al.

下部食道、食道胃接合部癌手術

下段食管及食管胃结合部癌手术

• 发表时间: 2010
• 期刊: 消化器外科
• 作者: 夏越祥次;その他
• 通讯作者: その他

Current Status and Future Perspective of Sentinel Node Navigation Surgery for Gastrointestinal Cancer

胃肠癌前哨淋巴结导航手术的现状和未来展望

• 发表时间: 2011
• 作者: 水口徹;他;Natsugoe S.
• 通讯作者: Natsugoe S.