Investigation of clinical significance of lymph node micro metastasis in gastro intestinal cancer.

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In the clinical significance of lymph node micrometastasis(LMM), LMM was examined by immunostaining and RT-PCR. The diagnosis of LMM is clinically useful for less invasive surgery such as sentinel node navigation surgery. Some genes related with lymph node metastasis were found by microaaray method. Such genes correlated well with clinical samples of gastrointestinal cancer. Preoperative chemo-radiation therapy was effective for LMM in esophageal cancer. The factors of lymphangiogenesis and chemokines were important for the formation and growth of LMM. In experimental study, a few cancer cells had growth ability and such result may offer important information for cancer treatment.