Novel approach of induction of donor specific immune tolerance: adoptive transfer of Treg cells combined with MF1 gene transfection
Novel approach of induction of donor specific immune tolerance: adoptive transfer of Treg cells combined with MF1 gene transfection
诱导供者特异性免疫耐受的新方法：Treg细胞过继转移结合MF1基因转染
批准号：
21390446
负责人：
AZUMA Haruhito
金额：
$10.98万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009-04-01 至 2014-03-31
中文摘要
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英文摘要
We have developed a novel approach of highly effective gene transfection technique using lenti-virus vector combined with ultrasound mediated gene transfection procedure. We have performed successful gene transfection of metron factor, which is the engineered chimeric factors containing selected functional domains of HGF and MSP, into the transplanted kidney tissue. Local production of MF-1, which may enhance the expansion of Treg cells in vivo, combined with .the adoptive transfer of Treg cells, successfully induced the donor specific immune tolerance in more than 70% of recipients in our rat kidney transplant model.
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DOI：
--
发表时间：
2009-07
期刊：
Anticancer research
影响因子：
2
作者：
[K. Takahara;H. Azuma;Takeshi Sakamoto;S. Kiyama;T. Inamoto;N. Ibuki;T. Nishida;H. Nomi;T. Ubai;N. Segawa;Y. Katsuoka]
通讯作者：
K. Takahara;H. Azuma;Takeshi Sakamoto;S. Kiyama;T. Inamoto;N. Ibuki;T. Nishida;H. Nomi;T. Ubai;N. Segawa;Y. Katsuoka
Rapid Increase of the Serum PSA Level in Response to High-intensity Focused Ultrasound Therapy may be a Potential Indicator of Biochemical Recurrence of Low-and Intermedicate-Risk Prostate Cancer
高强度聚焦超声治疗后血清 PSA 水平快速升高可能是低度和中度风险前列腺癌生化复发的潜在指标
高强度聚焦超声治疗后血清 PSA 水平快速升高可能是低度和中度风险前列腺癌生化复发的潜在指标
DOI：
--
发表时间：
2011
期刊：
Clinical Medicine Insights : Oncology
影响因子：
--
作者：
[Inamoto T, Komura K, Watsuji T, Azuma H]
通讯作者：
Azuma H
DOI：
10.1097/tp.0b013e3182007b59
发表时间：
2010-12-27
期刊：
TRANSPLANTATION
影响因子：
6.2
作者：
[Azuma, Haruhito, Isaka, Yoshitaka, Takahara, Shiro]
通讯作者：
Takahara, Shiro
今、求められる医療の実践を目指して
旨在实践现在需要的医疗服务
旨在实践现在需要的医疗服务
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
[Matsumoto K, Katsumata N, Saito I, Shibata T, Konishi I, Fukuda H, Kamura T., 東治人]
通讯作者：
東治人
Successful induction of donor-specific tolerance using Super-agonistic CD28 antibody in rat renal allografts
使用超激动 CD28 抗体在大鼠同种异体肾移植物中成功诱导供体特异性耐受
使用超激动 CD28 抗体在大鼠同种异体肾移植物中成功诱导供体特异性耐受
DOI：
--
发表时间：
2010
期刊：
影响因子：
--
作者：
[Azuma, H., Nomi, H., Ibuki, N., Inamoto, T., Isaka, Y., Takahara, S., Katsuoka, Y.]
通讯作者：
Y.
共 16 条
Novel bladder preservation therapy: BNCT-BOAI-Radiation, which selectively target cancer cells with very few complications
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批准号：24659718
-
项目类别：Grant-in-Aid for Challenging Exploratory Research
-
资助金额：$2.41万
-
财政年份：2012
-
负责人：AZUMA Haruhito
-
依托单位：
Novel cancer targeted organ preservation therapy, balloon occluded arterial infusion combined with boron neutron capture therapy, for invasive bladder cancer
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批准号：22659292
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项目类别：Grant-in-Aid for Challenging Exploratory Research
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资助金额：$2.06万
-
财政年份：2010
-
负责人：AZUMA Haruhito
-
依托单位：
A trial of permanent functional renal allografts : combined therapy using a novel approach involving induction of immune tolerance and MF1 gene transfection
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批准号：18390440
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项目类别：Grant-in-Aid for Scientific Research (B)
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资助金额：$8.2万
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财政年份：2006
-
负责人：AZUMA Haruhito
-
依托单位：
The effect of simultaneous transfection of HGF gene-plasmid and NFκB-decoy using ultrasound exposure with contrast agent in a rat kidney allograft model
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批准号：15390499
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项目类别：Grant-in-Aid for Scientific Research (B)
-
资助金额：$4.22万
-
财政年份：2003
-
负责人：AZUMA Haruhito
-
依托单位：