Novel cancer targeted organ preservation therapy, balloon occluded arterial infusion combined with boron neutron capture therapy, for invasive bladder cancer

新型癌症靶向器官保存疗法，球囊闭塞动脉灌注联合硼中子俘获疗法，治疗浸润性膀胱癌

• 批准号: 22659292
• 负责人: AZUMA Haruhito
• 金额: $ 2.06万
• 依托单位: Osaka Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659292/
• 关键词: 浸潤性膀胱癌; 硼素中性子捕捉療法; BNCT; 硼素; 標的粒子線治療; 硼素化合物; 膀胱温存療法; 加速器BNCT

Baloon occluded arterial infusion(BOAI) methods delivers an extremely high concentration of boron compounds, selectively to the site of a tumor. We have established a novel organ preservation therapy for invasive bladder cancer by combining BOAI with boron neutron capture therapy(BNCT), which damage specifically cancer cells without influencing surrounding tissues. We are now underway to produce the specific boron compounds, which selectively intrude into nuclei of cancer cells.

Baloon闭塞动脉输注（BOAI）方法将极高浓度的硼化合物选择性地输送到肿瘤部位。我们已经建立了一种新的器官保存治疗浸润性膀胱癌结合BOAI与硼中子捕获治疗（BNCT），专门损害癌细胞，而不影响周围组织。我们现在正在生产特定的硼化合物，它选择性地侵入癌细胞的细胞核。

项目成果

Utility of transrectal ultrasonography guidance and seven key elements of operative skill for early recovery of urinary continence after laparosconic radical prostatectomy

经直肠超声引导及手术技巧七要素在腹腔镜前列腺癌根治术后早期恢复尿失禁中的应用

• 发表时间: 2011
• 期刊: Int.J.Oncol.
• 作者: Azuma;H.;Ibuki;N.;Inamoto;T.;Koyama;K.;Utimoto;S.;Fujisue;Y.;Mizutani;Y.;Nomi;H.;Ubai;T.;Katsuoka;Y.
• 通讯作者: Y.

Utility of transrectal ultrasonography guidance and seven key elements of operative skill for early recovery of urinary continence after laparoscopic radical prostatectomy.

• DOI: 10.3892/ijo.2010.865
• 发表时间: 2011-02
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: H. Azuma;N. Ibuki;T. Inamoto;K. Koyama;Shinya Utimoto;Yutaka Fujisue;Y. Mizutani;H. Nomi;T. Ubai;Y. Katsuoka

Utility of the novel bladder preservation therapy, BOAI-CDDP-radiation(OMC-regimen), for elderly patients with invasive bladder cancer

新型膀胱保留疗法 BOAI-CDDP 放射（OMC 方案）在老年浸润性膀胱癌患者中的应用

• DOI: 10.3892/ijo_00000819
• 发表时间: 2011
• 期刊: Int. J. Oncol
• 作者: Azuma;H.;Inamoto;T.;Ibuki;N.;Ubai;T.;Kotake;Y.;Takahara;K.;Kiyama;S.;Nomi;H.;Uehara;H.;Komura;K.;Yamamoto;K.;Narumi;Y.;Katsuoka;Y
• 通讯作者: Y

局所浸潤性膀胱癌に対する、「血流閉塞バルーン付カテーテルを用いた抗癌剤動注(BOAI)+血液透析(膀胱潅流後抗癌剤除去)、および放射線照射併用療法」の治療効果

“血流阻断球囊导管抗癌剂动脉注射（BOAI）+血液透析（膀胱灌注后去除抗癌剂）和放射线照射”治疗局部浸润性膀胱癌的疗效

• 发表时间: 2010
• 作者: 東治人;稲元輝生;伊夫貴直和;小山耕平;内本晋也;藤末裕;枝川右;能見勇人;右梅貴信;勝岡洋治
• 通讯作者: 勝岡洋治

筋層浸潤膀胱癌に対しての膀胱温存療法

肌层浸润性膀胱癌的膀胱保留治疗

• 发表时间: 2011
• 作者: Azuma H;Inamoto;T.;Ibuki;N.;Ubai;T.;Kotake;Y.;Takahara;K.;Kiyama;S.;Nomi;H.;Uehara;H.;Komura;K.;Yamamoto;K.;Narumi;Y.;Katsuoka;Y.;東治人
• 通讯作者: 東治人