Searching newly targets and applying their antibodies for the periodontal disease, furthermore development of IT drugs.

分析TDC60的基因组信息有望为牙周炎的发病和进展机制提供新的见解。为此，我们使用完整的基因组序列搜索TDC60毒力因子，并使用2-DE和MALDI-TOF质谱仪发现与W83毒株相比，二肽酶PepD-2，Minor fimbire-1(Mfa1)，胶原酶Dap2的水平更高。对PepD和HBP35的晶体结构进行了整体折叠，并对其功能进行了分析。

Analyzing the genomic information for TDC60 is expected to provide new insights into the mechanisms underlying the onset and progression of periodontitis. For that reason, we searched for the specific virulence factor in the TDC60 strain using the complete genome sequences, and found higher levels of a dipeptidase PepD-2, a minor fimbire-1 (Mfa1), a collagenolysis-related peptidase Dap2 compared to the W83 strain using 2-DE and MALDI-TOF mass spectrometry. The crystal structure of PepD and HBP35 showed that the overall folding and then analyzed their function.