Searching newly targets and applying their antibodies for the periodontal disease, furthermore development of IT drugs.

分析TDC60的基因组信息有望为牙周炎发生和发展的机制提供新的见解。因此，我们使用全基因组序列搜索TDC60菌株的特定毒力因子，并使用2-DE和MALDI-TOF质谱分析发现，与W83菌株相比，TDC60菌株具有更高水平的二肽酶PepD-2、小纤维酶1 （Mfa1）、胶原溶解相关肽酶Dap2。对PepD和HBP35的晶体结构进行了整体折叠，并对其功能进行了分析。

Analyzing the genomic information for TDC60 is expected to provide new insights into the mechanisms underlying the onset and progression of periodontitis. For that reason, we searched for the specific virulence factor in the TDC60 strain using the complete genome sequences, and found higher levels of a dipeptidase PepD-2, a minor fimbire-1 (Mfa1), a collagenolysis-related peptidase Dap2 compared to the W83 strain using 2-DE and MALDI-TOF mass spectrometry. The crystal structure of PepD and HBP35 showed that the overall folding and then analyzed their function.