Development of intra-oral silica thin film coating method and synthesis of plaque controlling silane coupling agents.

我们用CO_2激光照射过氢聚硅氮烷(PHPS)和双氧水，在釉质表面成功地制备了二氧化硅薄膜。所制备的二氧化硅薄膜具有优异的显微硬度、耐磨性和耐酸性。这种二氧化硅涂层技术也可以应用于义齿基托树脂(PMMA)。并成功合成了一系列抗菌硅烷偶联剂。其中，10-I无细胞毒性，对口腔菌群有明显的抗菌作用。

We have succeeded to produce the silica thin film on enamel surface via CO_2 laser irradiation on the perhydropolysilazane(PHPS) and hydrogen peroxide applied enamel. The produced silica thin film showed excellent micro-hardness, abrasion and acid resistances. This silica coating technique was also able to apply to the denture base resin(PMMA). And we have successfully synthesized a number of antibacterial silane coupling agents. Of them, 10-I had no cytotoxicity and offered advantages in antibacterial effect for the oral bacterial flora.