The analysis of Ni allergy development and the therapeutic strategy in prosthodontics
The analysis of Ni allergy development and the therapeutic strategy in prosthodontics
批准号:
21390518
负责人:
ICHIKAWA Tetsuo
金额:
$11.4万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We analyzed Ni allergy symptoms in the mouse model which we produced. The major populations of infiltrated immune cells around the allergic region in skin were CD3 positive cells(T cells) and CD11c/ MHC classII positive cells(dendritic cells). p38/ MKK6 pathway in dendritic cells was activated by Ni stimulation both in vivo and in vitro.
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A novel therapy with manipulation of MKK6 gene on nickel allergy in mice
操纵MKK6基因治疗小鼠镍过敏的新疗法
DOI:
--
发表时间:
期刊:
PLoS ONE
影响因子:
3.7
作者:
[Megumi Watanabe, et al.]
通讯作者:
et al.
DOI:
10.1371/journal.pone.0019017
发表时间:
2011-04-22
期刊:
PloS one
影响因子:
3.7
作者:
[Watanabe M, Ishimaru N, Ashrin MN, Arakaki R, Yamada A, Ichikawa T, Hayashi Y]
通讯作者:
Hayashi Y
The Role of MKK6/p38 Signal Cascade in Dendritic Cells in Nickel Allergy Mouse Model
MKK6/p38 信号级联在镍过敏小鼠模型树突状细胞中的作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Watanabe, M]
通讯作者:
M
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Meinar Nur Asrin, Megumi Watanabe, Tetsuo Ichikawa et al.]
通讯作者:
Tetsuo Ichikawa et al.
The Role of MKK6/ p38 Signal Cascade in Dendritic Cells in Mickel Allergy Mouse Model
MKK6/p38 信号级联在 Mickel 过敏小鼠模型树突状细胞中的作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Mine, A., De Munck, J., Van Ende, A., Cardoso, M. V., Kuboki, T., Yoshida, Y., Van Meerbeek, B., Megumi Watanabe]
通讯作者:
Megumi Watanabe
共 11 条
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Three Dimensional examination of Bone-Implant interface using various implant materials
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海外基金