The analysis of Ni allergy development and the therapeutic strategy in prosthodontics

镍过敏发生发展分析及口腔修复治疗策略

• 批准号: 21390518
• 负责人: ICHIKAWA Tetsuo
• 金额: $ 11.4万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390518/
• 关键词: 金属アレルギー; 樹状細胞; MAPキナーゼ; ニッケル; T細胞

We analyzed Ni allergy symptoms in the mouse model which we produced. The major populations of infiltrated immune cells around the allergic region in skin were CD3 positive cells(T cells) and CD11c/ MHC classII positive cells(dendritic cells). p38/ MKK6 pathway in dendritic cells was activated by Ni stimulation both in vivo and in vitro.

我们对自制的小鼠模型进行了镍过敏症状分析。皮肤过敏区周围浸润的免疫细胞主要是CD3阳性细胞（T细胞）和CD11c/ MHC i类阳性细胞（树突状细胞）。在体内和体外实验中，Ni均激活了树突状细胞p38/ MKK6通路。

项目成果

A novel therapy with manipulation of MKK6 gene on nickel allergy in mice

操纵MKK6基因治疗小鼠镍过敏的新疗法

• 期刊: PLoS ONE
• 影响因子: 3.7
• 作者: Megumi Watanabe;et al.
• 通讯作者: et al.

A novel DC therapy with manipulation of MKK6 gene on nickel allergy in mice.

• DOI: 10.1371/journal.pone.0019017
• 发表时间: 2011-04-22
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Watanabe M;Ishimaru N;Ashrin MN;Arakaki R;Yamada A;Ichikawa T;Hayashi Y
• 通讯作者: Hayashi Y

The Role of MKK6/p38 Signal Cascade in Dendritic Cells in Nickel Allergy Mouse Model

MKK6/p38 信号级联在镍过敏小鼠模型树突状细胞中的作用

• 发表时间: 2011
• 作者: Watanabe;M
• 通讯作者: M

Analysis of Molecular Mechanism for Pathogenesis of Metal Allergy

金属过敏发病的分子机制分析

• 发表时间: 2010
• 作者: Meinar Nur Asrin;Megumi Watanabe;Tetsuo Ichikawa et al.
• 通讯作者: Tetsuo Ichikawa et al.

The Role of MKK6/ p38 Signal Cascade in Dendritic Cells in Mickel Allergy Mouse Model

MKK6/p38 信号级联在 Mickel 过敏小鼠模型树突状细胞中的作用

• 发表时间: 2011
• 作者: Mine;A.;De Munck;J.;Van Ende;A.;Cardoso;M. V.;Kuboki;T.;Yoshida;Y.;Van Meerbeek;B.;Megumi Watanabe
• 通讯作者: Megumi Watanabe