Study of cementogenesis and Wnt signaling

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Wnts are secreted glycoproteins that mediate developmental and post-developmental physiology through canonical and noncanonic al pathway. Although it appears that Wnt5a signaling supports normal bone physiology, the biological significa nce of noncanonical Wnts in osteogenesis is essentially unknown. In this study, we identified the expression of Wnt5a in osteoblasts in the tibial growth plate as well as bone marrow of rat tibia. Silencing gene expression of Wnt5a in cultured pre-osteobla st cells results in suppression of osteoblastic differen tiation, suggesting that Wnt5a signaling are of substantial importance for osteoblastic differentiation.