Study of Dentin regeneration based on extracellular calcium and phosphate.

重建龋齿中丢失的牙齿物质（牙本质）是牙科的一大目标。生长因子BMP-2调节成牙本质分化。我阐明了通过ERK/MAPK信号通路，在10 mM钙离子和3 mM无机磷酸盐的刺激下，BMP-2基因在人牙髓细胞中的表达增强。这一发现提示了未来在牙科治疗中提高BMP-2表达的可能性。

It is one of the big aims of dentistry to reproduce a tooth substance (dentin)which is lost in caries. Growth factor BMP-2 regulates odontoblastic differentiation to make dentin. I clarified that the expression of BMP-2 gene was enhanced in human pulp cells upon stimulation with not only 10 mM calcium ion but also 3 mM inorganic phosphate via ERK/MAPK signaling pathway. This finding suggested possibility to be connected for a cure to enhance expression of BMP-2 in dentistry in future.