Networking for research on human genetics of Tuberculosis

结核病人类遗传学研究网络

• 批准号: 21406006
• 负责人: TOKUNAGA Katsushi
• 金额: $ 11.15万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21406006/
• 关键词: 遺伝学; 感染症; 結核; ゲノム; 関連遺伝子; 国際共同研究; タイ; インドネシア; 遣伝学; トランスレーショナル・リサーチ

Tuberculosis(TB) is one of three major infectious diseases, affecting billions of people worldwide. Genome-wide association analyses in Thais and Japanese were carried out. The result of meta-analysis of young tuberculosis, an age subset GWAS was conducted in Thai and Japanese populations and a risk locus for young TB on 20q12 was identified. While the locus is located far from coding regions, the genes(HSPEP1-MAFB) close to this locus are promising candidates for tuberculosis susceptibility. We have collected samples based on our research network in Thailand, Japan, and Indonesia including age and pathogen information, which may accelerate the identification of the distinct host factors of TB.

结核病是全球影响数十亿人的三大传染病之一。对泰国人和日本人进行了全基因组关联分析。对青年结核病进行荟萃分析的结果是，在泰国和日本人群中进行了年龄子集GWAs，并确定了20q12青年结核病的危险基因。虽然该基因座位于远离编码区的地方，但接近该基因座的基因(HSPEP1-MAFB)是结核病易感性的潜在候选基因。我们基于我们在泰国、日本和印度尼西亚的研究网络收集了样本，包括年龄和病原体信息，这可能会加速识别结核病的不同宿主因素。

项目成果

Genome-wide SNP-based linkage analysis of tuberculosis in Thais

• DOI: 10.1038/gene.2008.81
• 发表时间: 2009-01-01
• 期刊: GENES AND IMMUNITY
• 影响因子: 5
• 作者: Mahasirimongkol, S.;Yanai, H.;Keicho, N.
• 通讯作者: Keicho, N.

Effect of age subset on genome-wide association analysis of tuberculosis in Thais

年龄子集对泰国结核病全基因组关联分析的影响

• 发表时间: 2011
• 作者: Mahasirimongkol S;et al.
• 通讯作者: et al.

Association of TLR polymorphisms with development of tuberculosis in Indonesian females

• DOI: 10.1111/j.1399-0039.2011.01821.x
• 发表时间: 2012-03-01
• 期刊: TISSUE ANTIGENS
• 作者: Kobayashi, K.;Yuliwulandari, R.;Tokunaga, K.
• 通讯作者: Tokunaga, K.

Candidate gene association analysis of single nucleotide polymorphism in NEMO with tuberculosis in Thailand Keystone Symposia Global Health Series

NEMO 单核苷酸多态性候选基因与泰国结核病的关联分析 Keystone Symposia 全球健康系列

• 发表时间: 2011
• 作者: Sukanya Wattanapokayakit;Surakameth Mahasirimongkol;Jurairut Phromjai;Amara Yowang;Watoo Promphittayasatit;Nuanjun Wichukchinda;Nusara Satproedprai;Wimala In-Unchot;Pathom Sawanpanyalert;Hideki Yanai;Taisei Mushiroda;Katsushi Tokunaga;Yusuke N
• 通讯作者: Yusuke N

東南アジア系集団における結核感受性とCD209遺伝子の関連

CD209基因与东南亚人群结核病易感性的关系

• 发表时间: 2010
• 作者: 小林杏輔;Rika Yuliwulandari;慶長直人;Nguyen Thi Le Hang;徳永勝士
• 通讯作者: 徳永勝士