Networking for research on human genetics of Tuberculosis

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Tuberculosis(TB) is one of three major infectious diseases, affecting billions of people worldwide. Genome-wide association analyses in Thais and Japanese were carried out. The result of meta-analysis of young tuberculosis, an age subset GWAS was conducted in Thai and Japanese populations and a risk locus for young TB on 20q12 was identified. While the locus is located far from coding regions, the genes(HSPEP1-MAFB) close to this locus are promising candidates for tuberculosis susceptibility. We have collected samples based on our research network in Thailand, Japan, and Indonesia including age and pathogen information, which may accelerate the identification of the distinct host factors of TB.