Study on interactions between infectious diseases and host genetic factors in East Asia and Oceania

东亚和大洋洲传染病与宿主遗传因素相互作用的研究

• 批准号: 11440248
• 负责人: TOKUNAGA Katsushi
• 金额: $ 9.66万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11440248/
• 关键词: Malaria; HTLV; G6PD defficiency; HLA; TNF-α; Papua New Guinea; Thailand; Duffy antigen; バンド3タンパク

(1) The significant association of TNFA promoter polymorphisms with cerebral malaria was found in malaria patients living in the northwest of Thailand. Also, we detected several HLA-DRB1 and -B alleles associated with severe or cerebral malaria. The TNFR2 polymorphism, 196M/R, was not associated with the disease severity in the malaria patients.(2) The Duffy antigen as a receptor for Plasmodium vivax and Plasmodium knowlesi was analyzed in the malaria-endemic regions of Southeast Asia and Oceania. The Fya-antigens found in this study showed weak reactivity to antisera. Such weak phenotypes are considered to have been maintained in the study populations due to a selective advantage through resistance to malaria.(3) Seroprevalence of antibodies to human T-lymphotropic virus type-1 (HTLV-1) was surveyed among the Thai population. Although Thailand is located between HTLV-1 harboring countries, HTLV-1 was found not to endemic in the Thai population.(4) HLA-DRB1 polymorphism was studied in the Gidra and Balopa populations of Papua New Guinea. The Balopa islanders showed a genetic similarity to Austronesian speaking groups in the Melanesia and also to the Gidra who are Non-Austronesian, while they are distant from the Polynesian and Micronesian populations. This result strongly suggests that the admixture between Austronesian and Non-Austronesian occurred in Papua New Guinea, regardless of their different language.

(1)在泰国西北部疟疾患者中发现TNFA启动子多态性与脑型疟疾有显著相关性。此外，我们还检测到几种与重度或脑型疟疾相关的HLA-DRB1和-B等位基因。在疟疾患者中，TNFR2多态性196M/R与疾病严重程度无关。(2)对东南亚和大洋洲疟疾流行地区间日疟原虫和诺氏疟原虫的Duffy抗原受体进行了分析。本研究发现的fya抗原对抗血清的反应性较弱。这种弱表型被认为在研究人群中由于通过抵抗疟疾的选择优势而得以维持。(3)调查了泰国人群中人类t淋巴细胞嗜型病毒（HTLV-1）抗体的血清阳性率。虽然泰国位于HTLV-1窝藏国之间，但HTLV-1并未在泰国人群中流行。(4)在巴布亚新几内亚的Gidra和Balopa人群中研究了HLA-DRB1多态性。巴洛帕岛民表现出与美拉尼西亚说南岛语的群体以及非南岛语的吉德拉人的遗传相似性，而他们与波利尼西亚和密克罗尼西亚人口相距遥远。这一结果有力地表明，南岛人和非南岛人之间的混合发生在巴布亚新几内亚，尽管他们的语言不同。

项目成果

Ohashi J, Yoshida M, et al.: "Analysis of HLA-DRB1 polymorphism in Gidra living in South New Guinea"Hum.Biol.. 72・2. 337-347 (2000)

Ohashi J，Yoshida M，等：“新几内亚南部的 Gidra 的 HLA-DRB1 多态性分析”Hum.Biol.. 72・2 (2000)。

Bannai M, Ohashi J, et al.: "Analysis of HLA genes and haplotypes in Ainu(from Hokkaido, northern Japan)supports the premise that they descent from Upper Paleolithic populations of East Asia."Tissue Antigens. 55・2. 128-139 (2000)

Bannai M、Ohashi J 等人：“对阿伊努人（来自日本北部北海道）的 HLA 基因和单倍型的分析支持了他们来自东亚旧石器时代晚期人群的前提。”组织抗原 55・2。 139（2000）

Inoue T, Ogawa A, Tokunaga K, Ishikawa Y, Kashiwase K, Tanaka H, Park MH, Jia GJ Chimge N-O, Sideltseva E, Akaza T, Tadokoro K, Takahashi T, and Juji T: "Diversity of HLA-B17 alleles and haplotypes in East Asians and a novel Cw6 allele (Cw^*0604) associat

Inoue T、Okawa A、Tokunaga K、Ishikawa Y、Kashiwase K、Tanaka H、Park MH、Jia GJ Chimge N-O、Sideltseva E、Akaza T、Tadokoro K、Takahashi T 和 Juji T：“HLA-B17 等位基因的多样性和

Ishida T, Appassakij H, et al: "Human T-lymphotropic retrovirus type-1 in Thailand."Southeast Asian Journal of Tropical Medicine and Public Health. 31・1. 1-3 (2000)

Ishida T、Appassakij H 等：“泰国人类 T 淋巴细胞逆转录病毒 1 型”。《东南亚热带医学与公共卫生杂志》31·1（2000 年）。

Shimizu Y, Ao H, et al.: "Sero-and molecular typing of Duffy blood group in Southeast Asians and Oceanians."Human Biology. 72.3. 511-518 (2000)

Shimizu Y、Ao H 等人：“东南亚人和大洋洲人达菲血型的血清和分子分型。”人类生物学。