International epidemiological studies and standar dization of diagnosis and treatment of autoimmune pulmonary alveolar proteinosis : Research basis of rare lung diseases.

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Pulmonary alveolar proteinosis(PAP) is a rare lung disease characterized by accumulation of surfactant-like materials in the lungs. Based on our new classification by auto-anti GM-CSF antibodies and our Japanese epidemiological data, we performed international standardization of measurements of the auto-antibodies and comparison of autoimmune PAP(collaboration of rare lung disease consortium, USA). We have shown our Japanese guideline for PAP in Europe, USA, and Asia, and preparation of international guideline is going on.