The novel roles of mast cells and fibroblasts in the tissue remodelling of pulmonary fibrosis

肥大细胞和成纤维细胞在肺纤维化组织重塑中的新作用

• 批准号: 14570573
• 负责人: INOUE Yoshikazu
• 金额: $ 2.24万
• 依托单位: National Kinki-Chuo Hospital for Chest Diseases, Clinical Research Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570573/
• 关键词: mast cells; fibroblasts; interstitial pneumonia; remodeling; MMP; bFGF; Flg; Bek; Tryptase; MMP-2; 特発性間質性肺炎; 肺リンパ脈管筋腫; 肺線維症

Mast cells are supposed to have important roles in tissue remodeling, angiogenesis, and fibrosis. In the lungs with pulmonary fibrosis, such as idiopathic pulmonary fibrosis, the number of basic fibroblast growth factor (bFGF) expressing mast cells (MCs) increases in the lungs with idiopathic pulmonary fibrosis (IPF), reflecting degree of fibrosis. In the fibrotic lungs, α-smooth muscle actin (SMA) positive myofibroblasts, type II pneumocytes, alveolar macrophages increased, and that those cells expressed the receptors of bFGF, such as Flg (FGFR1) and Bek (FGFR2). Mast cells may affect fibroproliferative response in IPF, suggesting bFGF may have roles in the fibtroproliferative responce. Interestingly, mast cells and fibroblats work together in the tissue remodelling, controlling the amount of bFGF, matrix metalloproteinases, tryptase, and collagen deposition, in vitro model.We conclude mast cells and fibroblasts have important roles in the tissue remodelling in the pulmonary fibrosis.

肥大细胞被认为在组织重塑、血管生成和纤维化中发挥重要作用。在特发性肺纤维化等肺纤维化中，表达碱性成纤维细胞生长因子(BFGF)的肥大细胞(MCs)在特发性肺纤维化(IPF)中的数量增加，反映了纤维化的程度。在纤维化肺中，α-平滑肌肌动蛋白阳性的肌成纤维细胞、II型肺泡巨噬细胞增多，这些细胞表达碱性成纤维细胞生长因子受体Flg(FGFR1)和Bek(FGFR2)。肥大细胞可能影响IPF的纤维增殖反应，提示碱性成纤维细胞生长因子可能在纤维增殖反应中发挥作用。有趣的是，在体外模型中，肥大细胞和成纤维细胞共同作用于组织重塑，控制碱性成纤维细胞生长因子、基质金属蛋白酶、类胰蛋白酶和胶原的沉积。

项目成果

Inoue K, Inoue Y, Arai T, Nawa Y, Kashiwa Y, Yamamoto S, Sakatani M: "Chronic eosinophilic pneumonia due to viceral larva migrans."Int, Med. 41. 478-482 (2002)

Inoue K、Inoue Y、Arai T、Nawa Y、Kashiwa Y、Yamamoto S、Sakatani M：“副幼虫移行症引起的慢性嗜酸性粒细胞性肺炎。”Int，Med。

井上義一: "特発性間質性肺炎と紛らわしい周辺疾患"呼吸器科. 1. 451-469 (2002)

Yoshikazu Inoue：“特发性间质性肺炎和易混淆的周围疾病”呼吸科1。451-469（2002）。

井上義一: "特発性肺線維症"新しい診断と治療のABC3/呼吸器. 3. 125-135 (2002)

Yoshikazu Inoue：“特发性肺纤维化”新诊断和治疗 ABC3/呼吸系统。 3. 125-135 (2002)

井上義一他: "間質性肺病変とKL-6,SP-A,SP-D:肺の画像から見て"日本胸部臨床. 61. 125-133 (2002)

Yoshikazu Inoue 等人：“间质性肺病变和 KL-6、SP-A、SP-D：从肺部图像观察”日本胸部诊所。 61. 125-133 (2002)

Wang T, Inoue Y, et al.: "L523S, an RNA-binding protein as a potential therapeutic target for lung cancer"Br J Cancer. 88. 887-894 (2003)

Wang T、Inoue Y 等人：“L523S，一种 RNA 结合蛋白，作为肺癌的潜在治疗靶点”Br J Cancer。