Research on the structural plasticity and pathogenesis of depressive disorders

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We carried out the neuroscience research on the morphological plasticity of neurons and glial cells constituting neuronal network, and obtained the following outcomes.(1) Adult neurogenesis in the dentate gyrus declined more severely in the ventral hippocampus than in the dorsal hippocampus.(2) Numerical densities of astrocytes increased in the stratum lacunosum-moleculare in the ventral hippocampus but not in the dorsal hippocampus with aging.(3) In the axotomy model, astrocytic, but not microglial, reaction may primarily mediate some anti-apoptotic effects through synaptic stripping.