Roles of monoaminergic and secretinergic regulations of synaptic transmission in cerebellar inhibitory synapses

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In this study, we examined a role of monoamines (noradrenaline (NA) and dopamine (DA)) and secretin on the synaptic transmission using rat cerebellum. 1) Pharmacological study revealed that presynaptic α2-adrenergic (α2-AR) and D2-like receptors (D2R) were activated by both NA and DA. Therefore, it is thought that cross-talk between these receptors play a role of sharing the modulatory action involving distinct monoaminergic controls in the cerebellum. 2) It is well known that neuropeptide secretin increases GABA release involving an activation of cAMP-PKA signal cascade onto inhibitory synapses at the cerebellar cortex. We found that new form of synaptic modulation involving the activation ofPLC-IP3 signal pathway at GABAergic synaptic terminals.