Roles of monoaminergic and secretinergic regulations of synaptic transmission in cerebellar inhibitory synapses

在这项研究中，我们研究了单胺(去甲肾上腺素(NA)和多巴胺(DA))和促胰液素在大鼠小脑突触传递中的作用。1)药理学研究表明，NA和DA均可激活突触前α2-肾上腺素能受体(α2-AR)和D2样受体(D2R)。因此，这些受体之间的串扰被认为起到了共同的调节作用，涉及小脑中不同的单胺能控制。2)已知神经肽促分泌素通过激活cAMP-PKA信号级联到小脑皮质抑制性突触来增加GABA的释放。我们发现在GABA能突触终末激活PLC-IP3信号通路是突触调制的新形式。

In this study, we examined a role of monoamines (noradrenaline (NA) and dopamine (DA)) and secretin on the synaptic transmission using rat cerebellum. 1) Pharmacological study revealed that presynaptic α2-adrenergic (α2-AR) and D2-like receptors (D2R) were activated by both NA and DA. Therefore, it is thought that cross-talk between these receptors play a role of sharing the modulatory action involving distinct monoaminergic controls in the cerebellum. 2) It is well known that neuropeptide secretin increases GABA release involving an activation of cAMP-PKA signal cascade onto inhibitory synapses at the cerebellar cortex. We found that new form of synaptic modulation involving the activation ofPLC-IP3 signal pathway at GABAergic synaptic terminals.