Roles of monoaminergic and secretinergic regulations of synaptic transmission in cerebellar inhibitory synapses

小脑抑制性突触中突触传递的单胺能和分泌能调节的作用

• 批准号: 21500375
• 负责人: SAITOW Fumihito
• 金额: $ 2.75万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500375/
• 关键词: ニューロン; シナプス; 神経回路; 小脳皮質; GABA; 修飾作用; セクレチン; モノアミン; シナプス修飾; 小脳

In this study, we examined a role of monoamines (noradrenaline (NA) and dopamine (DA)) and secretin on the synaptic transmission using rat cerebellum. 1) Pharmacological study revealed that presynaptic α2-adrenergic (α2-AR) and D2-like receptors (D2R) were activated by both NA and DA. Therefore, it is thought that cross-talk between these receptors play a role of sharing the modulatory action involving distinct monoaminergic controls in the cerebellum. 2) It is well known that neuropeptide secretin increases GABA release involving an activation of cAMP-PKA signal cascade onto inhibitory synapses at the cerebellar cortex. We found that new form of synaptic modulation involving the activation ofPLC-IP3 signal pathway at GABAergic synaptic terminals.

在这项研究中，我们研究了单胺（去甲肾上腺素（NA）和多巴胺（DA））和分泌素的作用，利用大鼠小脑的突触传递。1)药理学研究表明，突触前α2-肾上腺素能受体（α2-AR）和D2-样受体（D2-like receptor，D2 R）均被NA和DA激活，因此认为这两种受体之间的相互作用是共享小脑中涉及不同单胺能控制的调节作用。2)众所周知，神经肽促胰液素增加GABA的释放，涉及激活cAMP-PKA信号级联到小脑皮层的抑制性突触。在GABA能突触终末发现了一种新的突触调制形式，它涉及到PLC-IP 3信号通路的激活。

项目成果

Serotonin and Synaptic Transmission in the cerebellum. In Handbook of the Cerebellum and Cerebellar Disorders

小脑中的血清素和突触传递。

• 发表时间: 2012
• 作者: Saitow F;Hirono M;Suzuki H.
• 通讯作者: Suzuki H.

Murakoshi T Chronic stress enhances synaptic plasticity due to disinhibition in the anterior cingulate cortex and induces hyper-locomotion in mice.

Murakoshi T 慢性应激由于前扣带皮层的去抑制而增强突触可塑性，并诱导小鼠过度运动。

• 发表时间: 2010
• 期刊: Neuropharmacology
• 影响因子: 4.7
• 作者: Ito H;Nagano M;SuzukiH
• 通讯作者: SuzukiH

Monoaminergic cross-talk and mudulatory action of synaptic transmission in the deep cerebellar nuclei.

小脑深核中突触传递的单胺能串扰和调节作用。

• 发表时间: 2009
• 作者: Momose-Sato;Y.;Sato;K.;Takashi Murayama;知見聡美,太田力,佐藤朝子,笹岡俊邦,勝木元也,黒川信,南部篤;Saitow F et al.
• 通讯作者: Saitow F et al.

Modulatory effects of serotonin on glutamatergic synaptic transmission and long-term depression in the deep cerebellar nuclei

• DOI: 10.1016/j.neuroscience.2010.10.037
• 发表时间: 2011-01
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: M. Murano;F. Saitow;H. Suzuki

小脳核苔状線維におけるモノアミン作動性受容体のク

小脑核苔藓纤维中的单胺能受体激活

• 发表时间: 2012
• 作者: 水田恒太郎;藤田亜美;岳海源;蒋昌宇;井上将成;朴蓮花;楊柳;上村聡子;川崎弘貴;八坂敏一;熊本栄一;齋藤文仁ほか
• 通讯作者: 齋藤文仁ほか