Structural evaluation of stratum corneum investigated by electron spin resonance imaging

电子自旋共振(ESR)结合缓慢翻滚模拟被用来确定不同的角质层(SC)类脂结构。α-松油醇对单链5-DSA的渗透促进作用约为对照的3倍。我们还研究了寻常型银屑病(PV-SC)。我们发现，PV-SC的结构有序性低于对照SC，表明PV-SC的结构异常。建立了一台能够测量薄材料成像表面积的9 GHz ESR成像仪。更重要的是，TE111腔体不需要将样品插入腔体并将样品放置到ESR管中。此外，还开发了9 GHz成像仪的部件和成像数据处理。

Electron spin resonance (ESR) in conjunction with a slow-tumbling simulation was utilized for defining various stratum corneum (SC) lipid structures. The α-terpineol enhanced about three times permeation of the single chain 5-DSA than that of the control. We also studied psoriasis vulgaris SC (pv-SC). We found that the pv-SC is less ordering of the structure than that of the control SC, indicating abnormal architecture of the pv-sc.A 9 GHz ESR imager that is capable of the imaging surface area of thin materials has been built. More importantly, the TE111 cavity does not require inserting the sample into the cavity and placing samples into ESR tubes. In addition, the components of the 9 GHz imager and imaging data processing are developed.