Development of highly-sensitive time-resolved IR spectrometer to study the proton-pumping mechanisms of biomolecules
Development of highly-sensitive time-resolved IR spectrometer to study the proton-pumping mechanisms of biomolecules
开发高灵敏度时间分辨红外光谱仪来研究生物分子的质子泵浦机制
批准号：
21750022
负责人：
KUBO Minoru
金额：
$2.83万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2010
中文摘要
翻译
为了研究蛋白质的质子泵浦机制，研制了一种新型的高灵敏度红外光谱仪，可以在生理条件下测量蛋白质的纳秒时间分辨红外光谱。该光谱仪已应用于牛细胞色素C氧化酶的测定。阐明了该蛋白水通道门的动态调节机制。
英文摘要
A new highly-sensitive IR spectrometer that can measure nanosecond time-resolved IR spectra of proteins under physiological conditions has been developed to study the proton-pumping mechanisms of proteins. The spectrometer has been applied to bovine cytochrome c oxidase. The dynamic regulation mechanism of water channel gate of this protein is elucidated.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Vibrational coherence investigation of protein fluctuations for dynamic allostery
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批准号：24657107
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项目类别：Grant-in-Aid for Challenging Exploratory Research
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资助金额：$2.83万
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财政年份：2012
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负责人：KUBO Minoru
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依托单位：
Real-time observation of proton-pumping of membrane protein complexes using a novel high-sensitivity IR spectrometer
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批准号：23685040
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项目类别：Grant-in-Aid for Young Scientists (A)
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资助金额：$12.9万
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财政年份：2011
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负责人：KUBO Minoru
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依托单位：
海外基金