Development of Iron-Catalyzed Cross-coupling Reactions by Controlling Coordination

铁催化的交叉偶联反应的发展已经得到了深入的探索，但还没有很好地建立起来。通过配位控制，我们实现了氟化铁-NHC卡宾催化的联芳基交叉偶联和氯化铁-TMEDA催化的烷基-芳基偶联。在这个项目中，我们开展了一系列的机理研究，从芳纶(II)物种出发，揭示了铁(II)-(III)和(II)-(IV)的机理。基于这些机理，我们合成了新型的氯化铁-苯二膦配合物，使我们能够进行铁催化的Suzuki-Miyaura偶联反应。

Development of iron-catalyzed cross-coupling reactions have been intensively explored but not established well. We have developed biaryl cross-coupling using iron fluoride-NHC carbene catalyst and alkyl-aryl coupling using iron chloride-TMEDA catalyst with the aid of coordination control. In this project, we have carried out a series of mechanistic studies to reveal iron (II)-(III) and (II)-(IV) mechanism starting from aryliron (II) species. Based on these mechanisms, novel iron (II) chloride-phenylenediphosphine complexes have been synthesized, which enable us to develop iron-catalyzed Suzuki-Miyaura coupling reaction.