Identification of transporters involved in bittern excretion in marine teleost fish

参与海洋硬骨鱼卤水排泄的转运蛋白的鉴定

• 批准号: 21770077
• 负责人: KATO Akira
• 金额: $ 3万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21770077/
• 关键词: 生理学; 遺伝子; 海水適応; フグゲノム; イオントランスポーター; 尿細管; 近位尿細管; 近位尿細管尿細管

In marine teleost fish, dehydration is avoided through continuous drinking of seawater (SW) and subsequent elimination of excess, acquired ions from the gill (Na^+, Cl^-), intestine (Ca^<2+>, Mg^<2+>), and kidney (Mg^<2+>, SO_4^<2->, borate, Ca^<2+>). By the expression and functional analyses of ion transporters in the fugu kidney using fugu genome database, we identified ion transporters involved in renal excretion of SO_4^<2->, borate, and Ca^<2+>.

在海洋硬骨鱼中，通过持续饮用海水（SW）和随后从鳃（Na^+、Cl^-）、肠（Ca^2+、Mg^2+）和肾（Mg^2+、SO_4^<2->、硼酸盐、Ca^2+）中清除多余的离子来避免脱水。通过使用河豚基因组数据库对河豚肾脏离子转运蛋白的表达和功能进行分析，我们鉴定了参与肾脏排泄SO_4 ~+<2->、硼酸盐和Ca^&lt;2+&gt;的离子转运蛋白。

项目成果

Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure

• DOI: 10.1242/jeb.044719
• 发表时间: 2010-09-15
• 期刊: JOURNAL OF EXPERIMENTAL BIOLOGY
• 影响因子: 2.8
• 作者: Nawata, C. Michele;Hirose, Shigehisa;Kato, Akira
• 通讯作者: Kato, Akira

Molecular Physiology of Ammonia Excretion in the Pufferfish (Takifugu rubripes)

河豚（Takifugu rubripes）氨排泄的分子生理学

• 发表时间: 2010
• 作者: Nawata CM;Hirose S;Nakada T;Wood CM;Kato A
• 通讯作者: Kato A

Differential expression of Na+-Cl- cotransporter and Na+-K+-Cl- cotransporter 2 in the distal nephrons of euryhaline and seawater pufferfishes

• DOI: 10.1152/ajpregu.00725.2009
• 发表时间: 2011-02-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
• 影响因子: 2.8
• 作者: Kato, Akira;Muro, Takayuki;Hirose, Shigehisa
• 通讯作者: Hirose, Shigehisa

Mechanism of Borate Secretion by the Kidney of Seawater Fish.

海水鱼肾脏分泌硼酸盐的机制。

• 发表时间: 2010
• 作者: Kimura Y;Kurita Y;Kato A;Doi H;Hirose S.
• 通讯作者: Hirose S.

Regulation of electroneutral NaCl absorption by the small intestine.

• DOI: 10.1146/annurev-physiol-012110-142244
• 发表时间: 2011
• 期刊: Annual review of physiology
• 影响因子: 18.2
• 作者: Kato A;Romero MF
• 通讯作者: Romero MF