Study on chromosome de-condensation by analyzing the mechanism of condensin dissociation from mitotic chromosomes

染色体凝聚和分离是基因组信息从母体细胞精确传递到子代细胞的基本现象。在这项研究中，我们证明了染色体分离所必需的凝集素复合体在有丝分裂过程中对染色体具有持续的作用。凝聚素在有丝分裂过程中被修饰(磷酸化)，但当细胞从有丝分裂进入下一阶段(间期)时，这种修饰被移除。这些结果表明，凝聚素在有丝分裂过程中的持续作用及其修饰变化对于基因组信息的稳定传递和有丝分裂细胞向下一个细胞周期的进展具有重要意义。

Chromosome condensation and segregation are essential phenomena for precise transmission of genome information from mother to daughter cells. In this study, we showed that the condensin complex, which is necessary for chromosome segregation, has continuous role on chromosomes throughout mitosis. Condensin is modified (phosphorylated) during mitosis, but the modification is removed when cells exit from mitosis to next phase (interphase). These results suggest that continuous role of condensin throughout mitosis and its modification changes are important for the stable transmission of genome information and progression of mitotic cells to next cell cycle.