Analysis of non-muscle myosin II in left-right asymmetric morphogenesis of internal organ

许多动物的内脏都表现出典型的左右不对称。我们的遗传分析表明，非肌球蛋白II的激活是果蝇胚胎中肠LR不对称形态发生所必需的。在本研究中，我们试图探讨非肌球蛋白II的激活是否在LR形态发生中表现出LR偏向。因此，我们不能清楚地证实其LR偏向性激活，但我们证明了中肠LR不对称细胞运动依赖于非肌肉肌球蛋白II的激活。

Many animals exhibit stereotypical left-right (LR) asymmetry in their internal organs. From our genetic analysis, activation of non-muscle myosin II has been suggested to be required for LR asymmetric morphogenesis of the Drosophila embryonic midgut. In this study, we try to ask whether activation of non-muscle myosin II show LR bias in the LR morphogenesis. As a result, we could not clearly confirm its LR-biased activation, but we demonstrated that LR asymmetric cell movement of the midgut depended on non-muscle myosin II activation.