Analysis of non-muscle myosin II in left-right asymmetric morphogenesis of internal organ

非肌肉肌球蛋白II在内脏器官左右不对称形态发生中的分析

• 批准号: 21770243
• 负责人: OKUMURA Takashi
• 金额: $ 1.66万
• 依托单位: Gakushuin University (2010)Tokyo University of Science (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21770243/
• 关键词: 左右非対称性; ショウジョウバエ; 非筋定型ミオシンII; 消化管; 形態形成; Zipper; 発生生物学; ミオシンII; 内蔵筋

Many animals exhibit stereotypical left-right (LR) asymmetry in their internal organs. From our genetic analysis, activation of non-muscle myosin II has been suggested to be required for LR asymmetric morphogenesis of the Drosophila embryonic midgut. In this study, we try to ask whether activation of non-muscle myosin II show LR bias in the LR morphogenesis. As a result, we could not clearly confirm its LR-biased activation, but we demonstrated that LR asymmetric cell movement of the midgut depended on non-muscle myosin II activation.

许多动物的内脏表现出典型的左-右不对称。根据我们的遗传分析，非肌肉肌球蛋白II的激活被认为是果蝇胚胎中肠LR不对称形态发生所必需的。在这项研究中，我们试图询问非肌肉肌球蛋白II的激活是否在LR的形态发生中表现出LR偏向。因此，我们不能清楚地确认其偏向于LR的激活，但我们证明了LR不对称的中肠细胞运动依赖于非肌肉肌球蛋白II的激活。

项目成果

Left-right asymmetric morphogenesis of the anterior midgut depends on the activation of a non-muscle myosin II in Drosophila.

• DOI: 10.1016/j.ydbio.2010.05.501
• 发表时间: 2010-08
• 期刊: Developmental biology
• 影响因子: 2.7
• 作者: T. Okumura;Hiroo Fujiwara;Kiichiro Taniguchi;Junpei Kuroda;Naotaka Nakazawa;Mitsutoshi Nakamura;Ryo Hatori;Akira Ishio;Reo Maeda;K. Matsuno

A Drosophila GATA transcription factor gene, GATAe, is required for maintaining adult intestinal stem cells

果蝇 GATA 转录因子基因 GATAe 是维持成体肠道干细胞所必需的

• 发表时间: 2011
• 作者: Yoshimura Y.;Terabayashi T.;Miki H.;Takashi Okumura and Takashi Adachi-Yamada
• 通讯作者: Takashi Okumura and Takashi Adachi-Yamada

A novel Cre/loxP system for mosaic gene expression in the Drosophila embryo

• DOI: 10.1002/dvdy.23784
• 发表时间: 2012-05-01
• 期刊: DEVELOPMENTAL DYNAMICS
• 影响因子: 2.5
• 作者: Nakazawa, Naotaka;Taniguchi, Kiichiro;Matsuno, Kenji
• 通讯作者: Matsuno, Kenji

Three class I myosin genes have redundant and distinct function in Drosophila development

三个 I 类肌球蛋白基因在果蝇发育中具有冗余且独特的功能

• 发表时间: 2009
• 作者: Takashi Okumura;Shunya Hozumi;Kiichiro Taniguchi;Reo Maeda;Kenji Matsuno
• 通讯作者: Kenji Matsuno

Chirality in Planar Cell Shape Contributes to Left-Right Asymmetric Epithelial Morphogenesis

• DOI: 10.1126/science.1200940
• 发表时间: 2011-07-15
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Taniguchi, Kiichiro;Maeda, Reo;Matsuno, Kenji
• 通讯作者: Matsuno, Kenji