Studies on molecular mechanisms regulating intercellular communication in filamentous fungi, multicellular organisms

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Filamentous fungi grow as multicellular organisms, in which flanking cells communicate with each other via the septal pore. This project aimed to elucidate molecular mechanisms regulating the intercellular communication. AoSO that aggregates at the septal pore in response to stresses, and we identified protein regions responsible for the stress-responsive aggregation at the septal pore. Novel proteins localizing at the septal pore were identified through a screening for AoFus3 MAP kinase-interacting proteins.We discovered a novel function of peroxisomes for biotin biosynthesis during investigating biogenesis processes of Woronin body, an organelle that regulates the intercellular communication.