Control of expression of genes related to metabolic syndrome by food components

非酒精性脂肪性肝病(NAFLD)是代谢综合征中最常见的肝病。我们发现，饮食中摄取整个Panellus(Mukitake)粉末及其提取物可以缓解肥胖、糖尿病db/db小鼠的NAFLD。我们的研究表明，Mukitake至少表现出两种不同的生理作用来减轻NAFLD：一种是通过抑制MCP-1的产生来减轻炎症损伤，另一种是通过提高血清脂联素水平和防止内脏脂肪堆积来减轻炎症损伤。

Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in metabolic syndrome. We found that the dietary intake of powdered whole Panellus serotinus (Mukitake) and its extracts alleviate NAFLD in obese, diabetic db/db mice. Our study demonstrated that Mukitake displays at least two different physiological actions that alleviate NAFLD : one through the reduction of inflammatory damage by its suppression in MCP-1 production and the other through an increase of the serum adiponectin level and the prevention of visceral fat accumulation.