Identification of food components which regulate expression of genes related to metabolic syndrome

代谢综合征是导致心血管疾病发病率和死亡率增加的一组代谢紊乱。尤其是非酒精性脂肪性肝病（NAFLD）正在成为代谢综合征中最常见的肝病。我们发现饮食中摄入n-3 PUFA、n-3 polor lipid、植物提取物可减轻肥胖糖尿病db/db小鼠的NAFLD。我们的研究表明，这些功能性食物成分显示出至少两种不同的生理作用，可以缓解NAFLD：一种是通过抑制MCP-1的产生来减少炎症损伤，另一种是通过增加血清脂联素水平和预防内脏脂肪堆积。

The metabolic syndrome is a cluster of metabolic disorders that contribute to increased cardiovascular morbidity and mortality. Especially, nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in metabolic syndrome. We found that the dietary intake of n-3 PUFA, n-3 polor lipid, extracts from plants alleviate NAFLD in obese, diabetic db/db mice. Our study demonstrated that those functional food components display at least two different physiological actions that alleviate NAFLD: one through the reduction of inflammatory damage by its suppression in MCP-1 production and the other through an increase of the serum adiponectin level and the prevention of visceral fat accumulation.