Mechanistic Study on the Pro-oxidant Effects by Antioxidants

研究了在金属离子存在或碱性条件下，抗氧剂作为促氧化剂产生活性氧物种(ROS)的机理。槲皮素是一种多酚类抗氧化剂，通过其羰基氧与金属离子形成络合物来显示其促氧化活性。在强碱存在下，从维生素E模型中衍生出的酚酸阴离子表现出很强的给电子能力，能够还原分子氧生成ROS。

The mechanism of generation of reactive oxygen species (ROS) by antioxidants as pro-oxidants was investigated in the presence of a metal ion or under basic conditions. Quercetin, one of polyphenolic antioxidants, was suggested to show the pro-oxidant activity via a complex formation between its carbonyl oxygen and a metal ion. The phenolate anion derived from a vitamin E model in the presence of a strong base showed a strong electron-donating ability to reduce molecular oxygen to produce ROS.