Dose adjustment based on the developmental changes of drugmetabolic enzyme activity

根据药物代谢酶活性的发育变化调整剂量

• 批准号: 21790170
• 负责人: TAYAMA Yoshitaka
• 金额: $ 2.66万
• 依托单位: Hiroshima International University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790170/
• 关键词: 小児; 胎児; 新生児; 薬物代謝; 医薬品適正使用; 薬物代謝酵素; aldehyde oxidase; xanthine oxidase; 胎盤

In the present study, we observed the developmental changes of drag metabolic enzyme, xanthine oxidase (XO) and aldehyde oxidase (AO) activity in postnatal rat liver. On the other hands, there were no developmental changes of rat placenta XO and AO activity during gestational period. Account for the change of placenta weight, their activity in whole body may change during gestational period. Threfore, we should make dose adjustment based on the developmental changes of drag metabolic enzyme activity.

本研究观察了大鼠生后肝脏药物代谢酶黄嘌呤氧化酶（XO）和醛氧化酶（AO）活性的发育变化。大鼠胎盘XO和AO活性在妊娠期无发育变化。由于胎盘重量的变化，它们在整个妊娠期的活动可能发生变化。因此，应根据药物代谢酶活性的动态变化来调整剂量。

项目成果

ラット発育に伴う薬物代謝酵素xanthine oxidaseの活性変動

大鼠发育过程中药物代谢酶黄嘌呤氧化酶活性的变化

• 发表时间: 2011
• 作者: 田山剛崇

Effect oftea beverages on aldehyde oxidase activity

茶饮料对醛氧化酶活性的影响

• 发表时间: 2011
• 期刊: Drug Metab Pharmacokinet
• 作者: Tayama Y;Sugihara K;Sanoh S;MiyakeK;Morita S;Kitamura S;Ohta S.
• 通讯作者: Ohta S.