Dose adjustment based on the developmental changes of drugmetabolic enzyme activity
Dose adjustment based on the developmental changes of drugmetabolic enzyme activity
批准号:
21790170
负责人:
TAYAMA Yoshitaka
金额:
$2.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
In the present study, we observed the developmental changes of drag metabolic enzyme, xanthine oxidase (XO) and aldehyde oxidase (AO) activity in postnatal rat liver. On the other hands, there were no developmental changes of rat placenta XO and AO activity during gestational period. Account for the change of placenta weight, their activity in whole body may change during gestational period. Threfore, we should make dose adjustment based on the developmental changes of drag metabolic enzyme activity.
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会议论文
ラット発育に伴う薬物代謝酵素xanthine oxidaseの活性変動
大鼠发育过程中药物代谢酶黄嘌呤氧化酶活性的变化
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[田山剛崇]
通讯作者:
田山剛崇
Effect oftea beverages on aldehyde oxidase activity
茶饮料对醛氧化酶活性的影响
DOI:
--
发表时间:
2011
期刊:
Drug Metab Pharmacokinet
影响因子:
--
作者:
[Tayama Y, Sugihara K, Sanoh S, MiyakeK, Morita S, Kitamura S, Ohta S.]
通讯作者:
Ohta S.
Dose adjustment based on the developmental changes of drug metabolic enzyme activity and their pharmacological activity.
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批准号:23790212
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2011
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负责人:TAYAMA Yoshitaka
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依托单位:
海外基金