Molecular mechanism of serum amyloid signaling in lung metastasis

在肿瘤转移中，原发肿瘤分泌细胞因子以刺激远端器官诱导转移前阶段，这促进肿瘤细胞迁移。本项目通过动物模型、器官培养和细胞培养技术，揭示了仅位于终末细支气管的Clara细胞作为血清淀粉样蛋白A3级联的控制塔发挥作用，血清淀粉样蛋白A3级联是转移前阶段形成的罪魁祸首。

In tumor metastasis, primary tumor secretes cytokines to stimulate remote organs to induce a pre-metastatic phase, which facilitates tumor cells migration. This project revealed that Clara cell, located only in terminal bronchioles, functions as a control tower of serum amyloid A3 cascade, a culprit of the pre-metastatic phase formation, by using animal model, organ culture, and cell culture techniques.