Identification of the receptor for Bordetella dermonecrotic toxin.

本项目的目的是确定一个受体的博德特氏菌皮肤坏死毒素（DNT）。我已经确定了DNT与细胞结合的最小区域，并试图通过使用与该区域对应的合成肽来分离受体。功能性受体尚不清楚，需要进一步的实验来鉴定。在试图纯化受体时，我发现DNT与细胞外基质缔合。这种结合可能有助于毒素在体内对靶细胞的作用。

The aim of this project was to identify a receptor for Bordetella dermonecrotic toxin (DNT). I have determined the minimum region of DNT for cell binding, and attempted to isolate the receptor by using the synthetic peptide corresponding to the region. The functional receptor remains unknown and further trials would be needed to identify it. While attempting to purify the receptor, I found that DNT associates with the extracellular matrix. This association may facilitate the toxin action on target cells in vivo.