Molecular epidemiological study on the causative agent of cat scratch disease, Bartonella henselae

汉赛巴尔通体是猫抓病的病原体。我们描述了B的特征。使用基于DNA序列的基因分型方法从CSD患者和猫中分离出汉赛原虫。我们的研究表明，日本的人类感染可能是由B引起的。Henselae菌株在MST簇1中，不同于包含Houston-1和马赛型菌株的簇。在此基础上，我们建立了一种基于virB 5、bepA和badA三个毒力基因的基因分型方法，揭示了B的基因型分布。日本的henselae。

Bartonella henselae is the causative agent of cat scratch disease(CSD). We characterized B. henselae isolates from CSD patients and cats using DNA sequence-based genotyping methods. Our study demonstrated that human infections in Japan can be caused by B. henselae strains in MST cluster 1, distinct from clusters containing the Houston-1 and Marseille type strains. Furthermore, we developed a novel genotyping method based on three virulence genes(virB5, bepA and badA), and uncovered the genotypic distribution of B. henselae in Japan.